Nerve Growth Factor and the Role of Inflammation in Tumor Development-Reference-Cited by-同舟云学术

Nerve Growth Factor and the Role of Inflammation in Tumor Development

Published:2024-01-23 Issue:2 Volume:46 Page:965-989
ISSN:1467-3045
Container-title:Current Issues in Molecular Biology
language:en
Short-container-title:CIMB

Author:

Ferraguti Giampiero¹^ORCID,Terracina Sergio¹^ORCID,Tarani Luigi²^ORCID,Fanfarillo Francesca¹,Allushi Sara¹,Caronti Brunella³,Tirassa Paola⁴,Polimeni Antonella⁵^ORCID,Lucarelli Marco¹⁶^ORCID,Cavalcanti Luca⁷^ORCID,Greco Antonio⁷^ORCID,Fiore Marco⁴^ORCID

Affiliation:

1. Department of Experimental Medicine, Sapienza University of Rome, 00185 Rome, Italy

2. Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00185 Rome, Italy

3. Department of Human Neurosciences, Sapienza University Hospital of Rome, 00185 Rome, Italy

4. Institute of Biochemistry and Cell Biology (IBBC-CNR), Department of Sensory Organs, Sapienza University of Rome, 00185 Rome, Italy

5. Department of Odontostomatological and Maxillofacial Sciences, Sapienza University of Rome, 00185 Rome, Italy

6. Pasteur Institute, Cenci Bolognetti Foundation, Sapienza University of Rome, 00185 Rome, Italy

7. Department of Sensory Organs, Sapienza University of Rome, 00185 Rome, Italy

Abstract

Nerve growth factor (NGF) plays a dual role both in inflammatory states and cancer, acting both as a pro-inflammatory and oncogenic factor and as an anti-inflammatory and pro-apoptotic mediator in a context-dependent way based on the signaling networks and its interaction with diverse cellular components within the microenvironment. This report aims to provide a summary and subsequent review of the literature on the role of NGF in regulating the inflammatory microenvironment and tumor cell growth, survival, and death. The role of NGF in inflammation and tumorigenesis as a component of the inflammatory system, its interaction with the various components of the respective microenvironments, its ability to cause epigenetic changes, and its role in the treatment of cancer have been highlighted in this paper.

Publisher

MDPI AG

Link

https://www.mdpi.com/1467-3045/46/2/62/pdf

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