Dual Disseminated Aspergillosis and Mucormycosis Diagnosed at Autopsy: A Report of Two Cases of Coinfection and a Review of the Literature-Reference-Cited by-同舟云学术

Dual Disseminated Aspergillosis and Mucormycosis Diagnosed at Autopsy: A Report of Two Cases of Coinfection and a Review of the Literature

Published:2023-03-15 Issue:3 Volume:9 Page:357
ISSN:2309-608X
Container-title:Journal of Fungi
language:en
Short-container-title:JoF

Author:

Murray Jason¹^ORCID,Lu Zhen A.¹^ORCID,Miller Karin²,Meadows Alex¹,Totten Marissa¹,Zhang Sean X.¹

Affiliation:

1. Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA

2. Department of Pathology, Children’s Hospital Los Angeles, Los Angeles, CA 90027, USA

Abstract

Coinfection with invasive aspergillosis and mucormycosis in immunocompromised patients has been reported but is rarely confirmed by tissue histology or autopsy. Serum fungal biomarkers and culture are the primary diagnostic tools but are suboptimal for detecting fungal coinfection. Here, we present the cases of two patients who were immunocompromised due to hematologic malignancy where disseminated aspergillosis and mucormycosis coinfection was only diagnosed upon autopsy despite extensive fungal diagnostic workup, and also review recent literature of such instances of coinfection.

Funder

Johns Hopkins Pathology Department

Publisher

MDPI AG

Subject

Plant Science,Ecology, Evolution, Behavior and Systematics,Microbiology (medical)

Link

https://www.mdpi.com/2309-608X/9/3/357/pdf

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