Limited Impact of Delta Variant’s Mutations on the Effectiveness of Neutralization Conferred by Natural Infection or COVID-19 Vaccines in a Latino Population

Author:

Sariol Carlos A.ORCID,Serrano-Collazo CrisantaORCID,Ortiz Edwin J.,Pantoja Petraleigh,Cruz Lorna,Arana Teresa,Atehortua Dianne,Pabon-Carrero Christina,Espino Ana M.ORCID

Abstract

The SARS-CoV-2 pandemic has impacted public health systems all over the world. The Delta variant seems to possess enhanced transmissibility, but no clear evidence suggests it has increased virulence. Our data show that pre-exposed individuals had similar neutralizing activity against the authentic COVID-19 strain and the Delta and Epsilon variants. After only one vaccine dose, the neutralization capacity expanded to all tested variants in pre-exposed individuals. Healthy vaccinated individuals showed a limited breadth of neutralization. One vaccine dose did induce similar neutralizing antibodies against the Delta as against the authentic strain. However, even after two doses, this capacity only expanded to the Epsilon variant.

Funder

National Institute of Allergy and Infectious Diseases

University of Puerto Rico

Puerto Rico Science, Technology and Research Trust

Publisher

MDPI AG

Subject

Virology,Infectious Diseases

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