The Crucial Role of Inflammation and the Immune System in Colorectal Cancer Carcinogenesis: A Comprehensive Perspective-Reference-Cited by-同舟云学术

The Crucial Role of Inflammation and the Immune System in Colorectal Cancer Carcinogenesis: A Comprehensive Perspective

Published:2024-06-04 Issue:11 Volume:25 Page:6188
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Burgos-Molina Antonio Manuel¹^ORCID,Téllez Santana Teresa¹²³,Redondo Maximino¹²³⁴^ORCID,Bravo Romero María José¹

Affiliation:

1. Surgery, Biochemistry and Immunology Department, School of Medicine, University of Malaga, 29010 Málaga, Spain

2. Research Network on Chronic Diseases, Primary Care, and Health Promotion (RICAPPS), Carlos III Health Institute (Instituto de Salud Carlos III), Av. de Monforte de Lemos, 5, 28029 Madrid, Spain

3. Málaga Biomedical Research Institute (Instituto de Investigación Biomédica de Málaga, IBIMA), Calle Doctor Miguel Díaz Recio, 28, 29010 Málaga, Spain

4. Research Unit, Hospital Costa del Sol, Autovía A-7, km 187, 29603 Marbella, Spain

Abstract

Chronic inflammation drives the growth of colorectal cancer through the dysregulation of molecular pathways within the immune system. Infiltration of immune cells, such as macrophages, into tumoral regions results in the release of proinflammatory cytokines (IL-6; IL-17; TNF-α), fostering tumor proliferation, survival, and invasion. Tumors employ various mechanisms to evade immune surveillance, effectively ‘cloaking’ themselves from detection and subsequent attack. A comprehensive understanding of these intricate molecular interactions is paramount for advancing novel strategies aimed at modulating the immune response against cancer.

Funder

REDISSEC/RICAPPS

Instituto de Salud Carlos III

Publisher

MDPI AG

Link

https://www.mdpi.com/1422-0067/25/11/6188/pdf

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