Understanding the Role of Endothelial Cells in Glioblastoma: Mechanisms and Novel Treatments-Reference-Cited by-同舟云学术

Understanding the Role of Endothelial Cells in Glioblastoma: Mechanisms and Novel Treatments

Published:2024-06-01 Issue:11 Volume:25 Page:6118
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Hovis Gabrielle¹,Chandra Neha²,Kejriwal Nidhi²,Hsieh Kaleb Jia-Yi²,Chu Alison³,Yang Isaac¹⁴⁵⁶⁷^ORCID,Wadehra Madhuri²⁷^ORCID

Affiliation:

1. Department of Neurosurgery, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095, USA

2. Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095, USA

3. Division of Neonatology and Developmental Biology, Department of Pediatrics, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095, USA

4. Department of Radiation Oncology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095, USA

5. Department of Head and Neck Surgery, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095, USA

6. Lundquist Institute, Harbor-UCLA Medical Center, Torrance, CA 90502, USA

7. Jonsson Comprehensive Cancer Center, University of California-Los Angeles, Los Angeles, CA 90095, USA

Abstract

Glioblastoma is a highly aggressive neoplasm and the most common primary malignant brain tumor. Endothelial tissue plays a critical role in glioblastoma growth and progression, facilitating angiogenesis, cellular communication, and tumorigenesis. In this review, we present an up-to-date and comprehensive summary of the role of endothelial cells in glioblastomas, along with an overview of recent developments in glioblastoma therapies and tumor endothelial marker identification.

Funder

UCLA Visionary Ball Fund Grant, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research UCLA Scholars in Translational Medicine Program Award

UCLA Honberger Endowment Brain Tumor Research Seed Grant, and Stop Cancer (US) Development Award

Publisher

MDPI AG

Link

https://www.mdpi.com/1422-0067/25/11/6118/pdf

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