Comparative Bioinformatic Analysis Reveals Conserved Regions in SARS-CoV-2 Genome for RAPID Pandemic Response

Author:

Karpuj Marcela Viviana1ORCID,Shaytov D. R.1,Shemer-Avni Yonat2,Gideon Michael3,Frenkel Zakharia M.4,Sivan Sarit1ORCID

Affiliation:

1. Department of Biotechnology Engineering, Braude College of Engineering, Karmiel 2161002, Israel

2. Laboratory of Clinical Virology, Soroka University Medical Center, Beer-Sheva 84101, Israel

3. Department of Neurosurgery, Soroka Medical Center, Beer-Sheva 84101, Israel

4. Department of Software Engineering, Braude College of Engineering, Karmiel 2161002, Israel

Abstract

In the face of the SARS-CoV-2 pandemic, characterized by the virus’s rapid mutation rates, developing timely and targeted therapeutic and diagnostic interventions presents a significant challenge. This study utilizes bioinformatic analyses to pinpoint conserved genomic regions within SARS-CoV-2, offering a strategic advantage in the fight against this and future pathogens. Our approach has enabled the creation of a diagnostic assay that is not only rapid, reliable, and cost-effective but also possesses a remarkable capacity to detect a wide array of current and prospective variants with unmatched precision. The significance of our findings lies in the demonstration that focusing on these conserved genomic sequences can significantly enhance our preparedness for and response to emerging infectious diseases. By providing a blueprint for the development of versatile diagnostic tools and therapeutics, this research paves the way for a more effective global pandemic response strategy.

Publisher

MDPI AG

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