Applications of Stem Cell-Derived Extracellular Vesicles in Nerve Regeneration-Reference-Cited by-同舟云学术

Applications of Stem Cell-Derived Extracellular Vesicles in Nerve Regeneration

Published:2024-05-28 Issue:11 Volume:25 Page:5863
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Yavuz Burcak¹^ORCID,Mutlu Esra Cansever²^ORCID,Ahmed Zubair³^ORCID,Ben-Nissan Besim⁴,Stamboulis Artemis²^ORCID

Affiliation:

1. Vocational School of Health Services, Altinbas University, 34147 Istanbul, Turkey

2. Biomaterials Research Group, School of Metallurgy and Materials, College of Engineering and Physical Science, University of Birmingham, Birmingham B15 2TT, UK

3. Neuroscience & Ophthalmology, Institute of Inflammation and Ageing, University of Birmingham, Edgbaston B15 2TT, UK

4. Translational Biomaterials and Medicine Group, School of Life Sciences, University of Technology Sydney, P.O. Box 123, Broadway, NSW 2007, Australia

Abstract

Extracellular vesicles (EVs), including exosomes, microvesicles, and other lipid vesicles derived from cells, play a pivotal role in intercellular communication by transferring information between cells. EVs secreted by progenitor and stem cells have been associated with the therapeutic effects observed in cell-based therapies, and they also contribute to tissue regeneration following injury, such as in orthopaedic surgery cases. This review explores the involvement of EVs in nerve regeneration, their potential as drug carriers, and their significance in stem cell research and cell-free therapies. It underscores the importance of bioengineers comprehending and manipulating EV activity to optimize the efficacy of tissue engineering and regenerative therapies.

Funder

Health Institutes of Türkiye

Publisher

MDPI AG

Link

https://www.mdpi.com/1422-0067/25/11/5863/pdf

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