BCL11A Expression in Breast Cancer

Author:

Kątnik Ewa1,Gomułkiewicz Agnieszka1ORCID,Piotrowska Aleksandra1ORCID,Grzegrzółka Jędrzej1,Rusak Agnieszka1ORCID,Kmiecik Alicja1,Ratajczak-Wielgomas Katarzyna1ORCID,Dzięgiel Piotr1

Affiliation:

1. Division of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, 50-368 Wroclaw, Poland

Abstract

B-cell leukemia/lymphoma 11A (BCL11A) is a transcription factor that regulates the expression of genes involved in cell division or apoptosis. A link between high BCL11A expression and a worse prognosis has been demonstrated in patients with various cancers. The aim of this study was to investigate the expression pattern of BCL11A in breast cancer (BC) cases and mastopathy samples and to correlate the results with the clinicopathological data. The expression of the BCL11A protein was investigated using immunohistochemistry (IHC) on 200 cases of BC and 13 mastopathy samples. The level of BCL11A mRNA was determined using real-time PCR in 22 cases of BC and 6 mastopathy samples. The expression of BCL11A was also examined at the protein and mRNA levels in BC cell lines. A higher expression level of BCL11A in BC cases was shown compared to mastopathy samples. The expression level of BCL11A in BC cases and in the studied cell lines decreased with the increasing grade of histological malignancy (G). It was also negatively correlated with the primary tumor size. A significantly lower expression of BCL11A was found in BC that did not express estrogen or progesterone receptors and in triple-negative cases. The results of our research suggest that BCL11A may be relevant in the development of BC.

Publisher

MDPI AG

Subject

Microbiology (medical),Molecular Biology,General Medicine,Microbiology

Reference51 articles.

1. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries;Sung;CA Cancer J. Clin.,2021

2. Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries;Bray;CA Cancer J. Clin.,2018

3. Wojciechowska, U., and Didkowska, J. (2019, August 21). Zachorowania i Zgony Na Nowotwory Złośliwe w Polsce. Krajowy Rejestr Nowotworów, Centrum Onkologii—Instytut Im. Marii Skłodowskiej—Curie. Available online: http://onkologia.org.pl/raporty.

4. BCL11A Is a Triple-Negative Breast Cancer Gene with Critical Functions in Stem and Progenitor Cells;Khaled;Nat. Commun.,2015

5. Breast Cancer: Multiple Subtypes within a Tumor? Breast Cancer Stratification and Its Role in Guiding Therapeutic Decisions;Yeo;Trends Cancer,2018

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