The Link between Magnesium Supplements and Statin Medication in Dyslipidemic Patients

Author:

Nartea Roxana12ORCID,Mitoiu Brindusa Ilinca13,Ghiorghiu Ioana12ORCID

Affiliation:

1. Clinical Department 9, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania

2. National Institute for Rehabilitation, Physical Medicine and Balneoclimatology, 030079 Bucharest, Romania

3. Agrippa Ionescu Clinical Emergency Hospital, 077016 Bucharest, Romania

Abstract

Many investigations have discovered a connection between statins and magnesium supplements. On one hand, increasing research suggests that chronic hypomagnesemia may be an important factor in the etiology of some metabolic illnesses, including obesity and overweight, insulin resistance and type 2 diabetes mellitus, hypertension, alterations in lipid metabolism, and low-grade inflammation. Chronic metabolic problems seem to be prevented by a high Mg intake combined with diet and/or supplements. On the other hand, it is known that statins lower the frequency of cardiac events, stroke, and mortality, not by lowering LDL-C, but by the capacity to reduce mevalonate formation. That will enhance endothelial function, inhibit vascular smooth muscle cell proliferation and migration and encourage macrophages to promote plaque stability and regression while reducing inflammation. Taking these factors into consideration, we did an extensive analysis of the relevant literature, comparing the effects of Mg2 and statin medications on lipoproteins and, implicitly, on the key enzymes involved in cholesterol metabolism.

Funder

University of Medicine and Pharmacy Carol Davila

Publisher

MDPI AG

Subject

General Medicine

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