Megalin Expression in Primary Oral Squamous Cell Carcinoma Is Associated with the Presence of Lymph Node Metastases, Vascular Invasion, and Lower Overall Survival

Author:

Zulijani Ana12ORCID,Milardović Ana3,Kovač Zoran4ORCID,Perić Berislav5,Jakovac Hrvoje6ORCID

Affiliation:

1. Department of Oral Surgery, Clinical Hospital Center Rijeka, 51000 Rijeka, Croatia

2. Faculty of Dental Medicine, University of Rijeka, 51000 Rijeka, Croatia

3. Pediatric Intensive Care Unit, Clinical Hospital Center Rijeka, 51000 Rijeka, Croatia

4. Department of Prosthodontics, Faculty of Dental Medicine, University of Rijeka and Clinical Hospital Center Rijeka, 51000 Rijeka, Croatia

5. Department of Oral and Maxillofacial Surgery, University Hospital Dubrava, 10000 Zagreb, Croatia

6. Department of Physiology, Immunology and Pathophysiology, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia

Abstract

Megalin (LRP2) is a rapidly recycling multiligand endocytic receptor primarily expressed in polarized epithelial cells. Although megalin might be involved in tumor growth and invasiveness through several mechanisms, its role has been understudied in the field of molecular oncology so far. The present study aimed to evaluate the impact of megalin expression in oral squamous cell carcinoma (OSCC) on disease progression. Megalin expression was evaluated immunohistochemically in 63 OSCC specimens. Data obtained were retrospectively compared with patient clinicopathological features and their survival. The proportion of megalin-expressing cells in the primary OSCC tissue was significantly associated with metastatic spreading to lymph nodes, vascular invasion and lower overall survival rate. Results obtained by the study suggest that megalin can be considered as a novel molecule involved in OSCC pathogenesis, but also useful as a potential biomarker for cancer progression.

Funder

University of Rijeka

Publisher

MDPI AG

Subject

Microbiology (medical),Molecular Biology,General Medicine,Microbiology

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