HR Gene Variants Identified in Mexican Patients with Alopecia Areata

Author:

Ortiz-Ramírez Andrés12ORCID,Hernández-Jiménez María Cristina2,Guardiola-Avila Iliana Berenice3,De Luna-Santillana Erick de Jesús1ORCID,Oliva-Hernández Amanda Alejandra1,Altamirano-García María Lourdes4,Juárez-Rendón Karina Janett1ORCID

Affiliation:

1. Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Blvd. del Maestro s/n. Esq. Elías Piña, Col. Narciso Mendoza, Reynosa 88710, Mexico

2. Unidad Académica Multidisciplinaria Reynosa Aztlán, Universidad Autónoma de Tamaulipas, Calle 16 s/n y Lago de Chapala, Col. Aztlán, Reynosa 88740, Mexico

3. Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley (UTRGV), 5300 L. St., McAllen, TX 78504, USA

4. Centro Dermatológico Brunnenhalt de Reynosa, Vicente Guerrero 805 altos, Zona Centro, Reynosa 88500, Mexico

Abstract

Alopecia Areata (AA) is a multifactorial, dermatological disease characterized by non-scarring hair loss. Alterations in candidate genes, such as HR (Hairless), could represent a risk factor for its development. The aim of this study was to search for and analyze variants in exons 3, 15 and 17 of the HR gene in Mexican patients with AA. A total of 30 samples from both AA patients and healthy donors were analyzed in this study. Exons were amplified and sequenced using the Sanger method. Descriptive statistics and χ2 tests were used in the analysis of clinical–demographic characteristics and the comparison of allelic/genotypical frequencies between groups, respectively. The effect on protein function for the non-synonymous variants was determined with three bioinformatics servers. Three gene variants were identified in the HR gene of the evaluated patients. The benign polymorphism c.1010G > A p.(Gly337Asp) (rs12675375) had been previously reported, whereas the variants c.750G > A p.(Gln250Gln) and c.3215T > A (Val1072AGlu) have not been described in other world populations. Both non-synonymous variants proved to be significant (p ≤ 0.05). The variant c.3215T > A p.(Val1072Glu) is of particular interest due to its deleterious effect on the structure and function of the protein; therefore, it could be considered a risk factor for the development of AA.

Funder

Secretaría de Investigación y Posgrado of the Instituto Politécnico Nacional (IPN), Mexico

Publisher

MDPI AG

Subject

Microbiology (medical),Molecular Biology,General Medicine,Microbiology

Reference28 articles.

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3. Alopecia areata: A review of disease pathogenesis;Rajabi;Br. J. Dermatol.,2018

4. Epidemiologic and genetic characteristics of alopecia areata (part 1);Alzolibani;Acta Dermatovenerol. Alp Pannonica Adriat,2011

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