A Multimodal Approach for Clinical Diagnosis and Treatment of Primary Progressive Aphasia (MAINSTREAM): A Study Protocol

Author:

Cotelli Maria1,Baglio Francesca2ORCID,Manenti Rosa1ORCID,Blasi Valeria2,Galimberti Daniela34ORCID,Gobbi Elena1,Pagnoni Ilaria1,Rossetto Federica2,Rotondo Emanuela3ORCID,Esposito Valentina5,De Icco Roberto67ORCID,Giudice Carla67,Tassorelli Cristina67,Catricalà Eleonora8,Perini Giulia5ORCID,Alaimo Cristina1,Campana Elena1,Benussi Luisa9ORCID,Ghidoni Roberta9ORCID,Binetti Giuliano10,Carandini Tiziana3,Cappa Stefano Francesco58ORCID

Affiliation:

1. Neuropsychology Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy

2. IRCCS Fondazione Don Carlo Gnocchi ONLUS, 20148 Milan, Italy

3. Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy

4. Deparment of Biomedical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy

5. Dementia Research Center, IRCCS Mondino Foundation, 27100 Pavia, Italy

6. Department of Brain and Behavioral Sciences, University of Pavia, 27100 Pavia, Italy

7. Movement Analysis Research Unit, IRCCS Mondino Foundation, 27100 Pavia, Italy

8. ICoN Cognitive Neuroscience Center, Institute for Advanced Studies, IUSS, 27100 Pavia, Italy

9. Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy

10. MAC-Memory Clinic and Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy

Abstract

Primary Progressive Aphasia (PPA) is a syndrome due to different neurodegenerative disorders selectively disrupting language functions. PPA specialist care is underdeveloped. There are very few specialists (neurologists, psychiatrists, neuropsychologists, and speech therapists) and few hospital- or community-based services dedicated to the diagnosis and continuing care of people with PPA. Currently, healthcare systems struggle to provide adequate coverage of care that is too often fragmented, uncoordinated, and unresponsive to the needs of people with PPA and their families. Recently, attention has been gained by non-invasive brain stimulation techniques that allow a personalized treatment approach, such as transcranial Direct Current Stimulation (tDCS). The MAINSTREAM trial looks forward to introducing and evaluating therapeutic innovations such as tDCS coupled with language therapy in rehabilitation settings. A Multimodal Approach for Clinical Diagnosis and Treatment of Primary Progressive Aphasia, MAINSTREAM (ID: 3430931) was registered in the clinicaltrials.gov database (identifier: NCT05730023) on 15 February 2023.

Funder

Fondazione Regionale per la Ricerca Biomedica (FRRB)-UNMET MEDICAL NEEDS—Regione Lombardia

Publisher

MDPI AG

Subject

General Neuroscience

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