Affiliation:
1. Laboratory of Cellular & Molecular Neurobiology, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
2. Laboratory of Applied Microbiology, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
Abstract
Parkinson’s disease (PD) is the second most common progressive neurodegenerative disorder after Alzheimer’s disease. Pathophysiologically, it is characterized by intracytoplasmic aggregates of α-synuclein protein in the Lewy body and loss of dopaminergic neurons from substantia nigra pars compacta and striatum regions of the brain. Although the exact mechanism of neurodegeneration is not fully elucidated, it has been reported that environmental toxins such as MPTP, rotenone, paraquat, and MPP+ induce oxidative stress, which is one of the causative factors for it. To date, there is no complete cure. However, the indispensable role of oxidative stress in mediating PD indicates that antioxidant therapy could be a possible therapeutic strategy against the disease. The deficiency of vitamins has been extensively co-related to PD. Dietary supplementation of vitamins with antioxidant, anti-inflammatory, anti-apoptotic, and free radical scavenging properties could be the potential neuroprotective therapeutic strategy. This review summarizes the studies that evaluated the role of vitamins (A, B, C, D, E, and K) in PD. It will guide future studies in understanding the potential therapeutic role of vitamins in disease pathophysiology and may provide a framework for designing treatment strategies against the disease.
Reference83 articles.
1. Retinol (vitamin A) increases α-synuclein, β-amyloid peptide, tau phosphorylation and RAGE content in human SH-SY5Y neuronal cell line;Kunzler;Neurochem. Res.,2017
2. Evaluating dose-and time-dependent effects of vitamin c treatment on a parkinson’s disease fly model;Linh;Park. Dis.,2019
3. The effects of retinol oral supplementation in 6-hydroxydopamine dopaminergic denervation model in Wistar rats;Kunzler;Neurochem. Int.,2019
4. Giri, B., Belanger, K., Seamon, M., Bradley, E., Purohit, S., Chong, R., Morgan, J.C., Baban, B., and Wakade, C. (2019). Niacin ameliorates neuro-inflammation in Parkinson’s disease via GPR109A. Int. J. Mol. Sci., 20.
5. Neutrophil-to-lymphocyte ratio (NLR) at boundaries of Progressive Supranuclear Palsy Syndrome (PSPS) and Corticobasal Syndrome (CBS);Alster;Neurol. I Neurochir. Pol.,2021