Abstract
Alzheimer’s disease is one of the most common age-related neurodegenerative disorders. The main theory of Alzheimer’s disease progress is the amyloid-β cascade hypothesis. However, the initial mechanisms of insoluble forms of amyloid-β formation and hyperphosphorylated tau protein in neurons remain unclear. One of the factors, which might play a key role in senile plaques and tau fibrils generation due to Alzheimer’s disease, is inflammaging, i.e., systemic chronic low-grade age-related inflammation. The activation of the proinflammatory cell phenotype is observed during aging, which might be one of the pivotal mechanisms for the development of chronic inflammatory diseases, e.g., atherosclerosis, metabolic syndrome, type 2 diabetes mellitus, and Alzheimer’s disease. This review discusses the role of the inflammatory processes in developing neurodegeneration, activated during physiological aging and due to various diseases such as atherosclerosis, obesity, type 2 diabetes mellitus, and depressive disorders.
Reference207 articles.
1. World Health Organizatios (WHO) (2022, July 20). Ageing and Health. Available online: https://www.who.int/news-room/fact-sheets/detail/ageing-and-health.
2. Inflammation: The Link between Comorbidities, Genetics, and Alzheimer’s Disease;Newcombe;J. Neuroinflamm.,2018
3. Libertini, G., Graziamaria, C., Valeria, C., Olga, S., and Nicola, F. (2021). Evolutionary Gerontology and Geriatrics: Why and How We Age, Springer.
4. New Data on Biochemical Mechanism of Programmed Senescence of Organisms and Antioxidant Defense of Mitochondria;Skulachev;Biochemistry,2009
5. Replicative Senescence and Expression of Autophagy Genes in Mesenchymal Stromal Cells;Ratushnyy;Biochemistry,2020
Cited by
24 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献