Alzheimer’s Disease and Inflammaging

Author:

Kosyreva AnnaORCID,Sentyabreva AlexandraORCID,Tsvetkov IvanORCID,Makarova Olga

Abstract

Alzheimer’s disease is one of the most common age-related neurodegenerative disorders. The main theory of Alzheimer’s disease progress is the amyloid-β cascade hypothesis. However, the initial mechanisms of insoluble forms of amyloid-β formation and hyperphosphorylated tau protein in neurons remain unclear. One of the factors, which might play a key role in senile plaques and tau fibrils generation due to Alzheimer’s disease, is inflammaging, i.e., systemic chronic low-grade age-related inflammation. The activation of the proinflammatory cell phenotype is observed during aging, which might be one of the pivotal mechanisms for the development of chronic inflammatory diseases, e.g., atherosclerosis, metabolic syndrome, type 2 diabetes mellitus, and Alzheimer’s disease. This review discusses the role of the inflammatory processes in developing neurodegeneration, activated during physiological aging and due to various diseases such as atherosclerosis, obesity, type 2 diabetes mellitus, and depressive disorders.

Publisher

MDPI AG

Subject

General Neuroscience

Reference207 articles.

1. World Health Organizatios (WHO) (2022, July 20). Ageing and Health. Available online: https://www.who.int/news-room/fact-sheets/detail/ageing-and-health.

2. Inflammation: The Link between Comorbidities, Genetics, and Alzheimer’s Disease;Newcombe;J. Neuroinflamm.,2018

3. Libertini, G., Graziamaria, C., Valeria, C., Olga, S., and Nicola, F. (2021). Evolutionary Gerontology and Geriatrics: Why and How We Age, Springer.

4. New Data on Biochemical Mechanism of Programmed Senescence of Organisms and Antioxidant Defense of Mitochondria;Skulachev;Biochemistry,2009

5. Replicative Senescence and Expression of Autophagy Genes in Mesenchymal Stromal Cells;Ratushnyy;Biochemistry,2020

Cited by 36 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3