Author:
Geng Xinling,Fan Xiwang,Zhong Yiwen,Casanova Manuel F.,Sokhadze Estate M.,Li Xiaoli,Kang Jiannan
Abstract
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder that interferes with normal brain development. Brain connectivity may serve as a biomarker for ASD in this respect. This study enrolled a total of 179 children aged 3−10 years (90 typically developed (TD) and 89 with ASD). We used a weighted phase lag index and a directed transfer function to investigate the functional and effective connectivity in children with ASD and TD. Our findings indicated that patients with ASD had local hyper-connectivity of brain regions in functional connectivity and simultaneous significant decrease in effective connectivity across hemispheres. These connectivity abnormalities may help to find biomarkers of ASD.
Funder
National Natural Science Foundation of China
Science and Technology Development Fund of Shanghai Pudong New Area
Medical discipline Construction Project of Pudong Health Committee of Shanghai
Research Project of Shanghai Science and Technology Commission
Cited by
9 articles.
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