Intracranial Aneurysms and Genetics: An Extensive Overview of Genomic Variations, Underlying Molecular Dynamics, Inflammatory Indicators, and Forward-Looking Insights

Author:

Toader Corneliu12,Eva Lucian34,Bratu Bogdan-Gabriel1,Covache-Busuioc Razvan-Adrian1,Costin Horia Petre1ORCID,Dumitrascu David-Ioan1ORCID,Glavan Luca-Andrei1,Corlatescu Antonio Daniel1,Ciurea Alexandru Vlad15

Affiliation:

1. Department of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania

2. Department of Vascular Neurosurgery, National Institute of Neurology and Neurovascular Diseases, 077160 Bucharest, Romania

3. Department of Neurosurgery, Dunarea de Jos University, 800010 Galati, Romania

4. Department of Neurosurgery, Clinical Emergency Hospital “Prof. Dr. Nicolae Oblu”, 700309 Iasi, Romania

5. Neurosurgery Department, Sanador Clinical Hospital, 010991 Bucharest, Romania

Abstract

This review initiates by outlining the clinical relevance of IA, underlining the pressing need to comprehend its foundational elements. We delve into the assorted risk factors tied to IA, spotlighting both environmental and genetic influences. Additionally, we illuminate distinct genetic syndromes linked to a pronounced prevalence of intracranial aneurysms, underscoring the pivotal nature of genetics in this ailment’s susceptibility. A detailed scrutiny of genome-wide association studies allows us to identify key genomic changes and locations associated with IA risk. We further detail the molecular and physiopathological dynamics instrumental in IA’s evolution and escalation, with a focus on inflammation’s role in affecting the vascular landscape. Wrapping up, we offer a glimpse into upcoming research directions and the promising horizons of personalized therapeutic strategies in IA intervention, emphasizing the central role of genetic insights. This thorough review solidifies genetics’ cardinal role in IA, positioning it as a cornerstone resource for professionals in the realms of neurology and genomics.

Publisher

MDPI AG

Subject

General Neuroscience

Reference121 articles.

1. Unruptured Intracranial Aneurysms;Brown;Semin. Neurol.,2010

2. Prevalence and Risk of Rupture of Intracranial Aneurysms: A Systematic Review;Rinkel;Stroke,1998

3. Levy, M.L., Levy, D.M., and Manna, B. (2023, August 10). Pediatric Cerebral Aneurysm, StatPearls, Available online: http://www.ncbi.nlm.nih.gov/books/NBK537085/.

4. Incidence and prevalence of intracranial aneurysms and hemorrhage in Olmsted County, Minnesota, 1965 to 1995;Menghini;Neurology,1998

5. Clinical analysis of incidentally discovered unruptured aneurysms;Ujiie;Stroke,1993

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