Verbal Learning and Memory Deficits across Neurological and Neuropsychiatric Disorders: Insights from an ENIGMA Mega Analysis

Author:

Kennedy Eamonn123,Liebel Spencer W.13,Lindsey Hannah M.13ORCID,Vadlamani Shashank1,Lei Pui-Wa4ORCID,Adamson Maheen M.56ORCID,Alda Martin7ORCID,Alonso-Lana Silvia8910,Anderson Tim J.111213,Arango Celso914,Asarnow Robert F.151617,Avram Mihai18,Ayesa-Arriola Rosa919,Babikian Talin1520,Banaj Nerisa21ORCID,Bird Laura J.22ORCID,Borgwardt Stefan1823ORCID,Brodtmann Amy2425ORCID,Brosch Katharina2627,Caeyenberghs Karen28,Calhoun Vince D.29,Chiaravalloti Nancy D.3031,Cifu David X.32ORCID,Crespo-Facorro Benedicto933,Dalrymple-Alford John C.111234ORCID,Dams-O’Connor Kristen3536,Dannlowski Udo37,Darby David383940,Davenport Nicholas4142,DeLuca John3143ORCID,Diaz-Caneja Covadonga M.14,Disner Seth G.4142,Dobryakova Ekaterina3144,Ehrlich Stefan4546ORCID,Esopenko Carrie35ORCID,Ferrarelli Fabio47ORCID,Frank Lea E.48,Franz Carol E.4950,Fuentes-Claramonte Paola89ORCID,Genova Helen3151,Giza Christopher C.205253,Goltermann Janik37,Grotegerd Dominik37,Gruber Marius3754,Gutierrez-Zotes Alfonso95556,Ha Minji57ORCID,Haavik Jan5859ORCID,Hinkin Charles15,Hoskinson Kristen R.6061ORCID,Hubl Daniela62,Irimia Andrei636465,Jansen Andreas26,Kaess Michael6667,Kang Xiaojian5,Kenney Kimbra68ORCID,Keřková Barbora69ORCID,Khlif Mohamed Salah70,Kim Minah7172,Kindler Jochen66,Kircher Tilo26,Knížková Karolina6973ORCID,Kolskår Knut K.747576,Krch Denise3144ORCID,Kremen William S.4950,Kuhn Taylor15,Kumari Veena77,Kwon Junsoo577172ORCID,Langella Roberto21,Laskowitz Sarah78,Lee Jungha57,Lengenfelder Jean3144,Liou-Johnson Victoria5ORCID,Lippa Sara M.7980,Løvstad Marianne7576,Lundervold Astri J.81ORCID,Marotta Cassandra3839,Marquardt Craig A.4142ORCID,Mattos Paulo82,Mayeli Ahmad47ORCID,McDonald Carrie R.8384,Meinert Susanne3785,Melzer Tracy R.111234ORCID,Merchán-Naranjo Jessica14,Michel Chantal66ORCID,Morey Rajendra A.7886,Mwangi Benson87,Myall Daniel J.12ORCID,Nenadić Igor26,Newsome Mary R.13,Nunes Abraham788ORCID,O’Brien Terence2589,Oertel Viola90,Ollinger John79,Olsen Alexander919293ORCID,Ortiz García de la Foz Victor19,Ozmen Mustafa294,Pardoe Heath40ORCID,Parent Marise95ORCID,Piras Fabrizio21,Piras Federica21ORCID,Pomarol-Clotet Edith89,Repple Jonathan3754,Richard Geneviève74ORCID,Rodriguez Jonathan49,Rodriguez Mabel69,Rootes-Murdy Kelly29ORCID,Rowland Jared969798ORCID,Ryan Nicholas P.99100ORCID,Salvador Raymond89ORCID,Sanders Anne-Marthe747576,Schmidt Andre101,Soares Jair C.87,Spalleta Gianfranco21ORCID,Španiel Filip69102ORCID,Sponheim Scott R.4142,Stasenko Alena4984,Stein Frederike26,Straube Benjamin26ORCID,Thames April15,Thomas-Odenthal Florian26,Thomopoulos Sophia I.103,Tone Erin B.104ORCID,Torres Ivan105106,Troyanskaya Maya107108,Turner Jessica A.109,Ulrichsen Kristine M.747576,Umpierrez Guillermo110,Vecchio Daniela21ORCID,Vilella Elisabet95556ORCID,Vivash Lucy3839,Walker William C.111112ORCID,Werden Emilio40,Westlye Lars T.7475113,Wild Krista114,Wroblewski Adrian26,Wu Mon-Ju87ORCID,Wylie Glenn R.31115,Yatham Lakshmi N.105,Zunta-Soares Giovana B.87,Thompson Paul M.103116,Pugh Mary Jo12ORCID,Tate David F.13,Hillary Frank G.117118119ORCID,Wilde Elisabeth A.13,Dennis Emily L.13ORCID

Affiliation:

1. Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA

2. Division of Epidemiology, University of Utah, Salt Lake City, UT 84108, USA

3. George E Wahlen Veterans Affairs Medical Center, Salt Lake City, UT 84148, USA

4. Department of Educational Psychology, Counseling, and Special Education, Pennsylvania State University, University Park, PA 16802, USA

5. WRIISC-WOMEN & Rehabilitation Department, VA Palo Alto, Palo Alto, CA 94304, USA

6. Neurosurgery, Stanford School of Medicine, Stanford, CA 94305, USA

7. Department of Psychiatry, Dalhousie University, Halifax, NS B3H 4R2, Canada

8. FIDMAG Research Foundation, 08025 Barcelona, Spain

9. Centro Investigación Biomédica en Red Salud Mental (CIBERSAM), 28029 Madrid, Spain

10. Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08022 Barcelona, Spain

11. Department of Medicine, University of Otago, Christchurch 8011, New Zealand

12. New Zealand Brain Research Institute, Christchurch 8011, New Zealand

13. Department of Neurology, Te Whatu Ora–Health New Zealand Waitaha Canterbury, Christchurch 8011, New Zealand

14. Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), School of Medicine, Universidad Complutense, 28040 Madrid, Spain

15. Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA 90095, USA

16. Brain Research Institute, University of California Los Angeles, Los Angeles, CA 90095, USA

17. Department of Psychology, University of California Los Angeles, Los Angeles, CA 90095, USA

18. Translational Psychiatry, Department of Psychiatry and Psychotherapy, University of Lübeck, 23562 Lübeck, Germany

19. Department of Psychiatry, Marqués de Valdecilla University Hospital, Instituto de Investigación Sanitaria Valdecilla (IDIVAL), School of Medicine, University of Cantabria, 39008 Santander, Spain

20. UCLA Steve Tisch BrainSPORT Program, University of California Los Angeles, Los Angeles, CA 90095, USA

21. Laboratory of Neuropsychiatry, Santa Lucia Foundation IRCCS, 00179 Rome, Italy

22. School of Clinical Sciences, Monash University, Clayton, VIC 3800, Australia

23. Center of Brain, Behaviour and Metabolism (CBBM), University of Lübeck, 23562 Lübeck, Germany

24. Cognitive Health Initiative, School of Translational Medicine, Monash University, Melbourne, VIC 3800, Australia

25. Department of Medicine, Royal Melbourne Hospital, Melbourne, VIC 3050, Australia

26. Department of Psychiatry and Psychotherapy, University of Marburg, 35032 Marburg, Germany

27. Institute of Behavioral Science, Feinstein Institutes for Medical Research, Manhasset, NY 11030, USA

28. Cognitive Neuroscience Unit, School of Psychology, Deakin University, Burwood, VIC 3125, Australia

29. Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State, Georgia Tech, Emory University, Atlanta, GA 30322, USA

30. Centers for Neuropsychology, Neuroscience & Traumatic Brain Injury Research, Kessler Foundation, East Hanover, NJ 07936, USA

31. Department of Physical Medicine & Rehabilitation, Rutgers, New Jersey Medical School, Newark, NJ 07103, USA

32. Rehabilitation Medicine Department, National Institutes of Health Clinical Center, Bethesda, MD 20892, USA

33. Department of Psychiatry, Virgen del Rocio University Hospital, School of Medicine, University of Seville, IBIS, 41013 Seville, Spain

34. School of Psychology, Speech and Hearing, University of Canterbury, Christchurch 8041, New Zealand

35. Department of Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA

36. Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA

37. Institute for Translational Psychiatry, University of Münster, 48149 Münster, Germany

38. Department of Neuroscience, Monash University, Melbourne, VIC 3800, Australia

39. Department of Neurology, Alfred Health, Melbourne, VIC 3004, Australia

40. The Florey Institute of Neuroscience and Mental Health, Melbourne, VIC 3052, Australia

41. Department of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN 55455, USA

42. Minneapolis VA Health Care System, Minneapolis, MN 55417, USA

43. Kessler Foundation, East Hanover, NJ 07936, USA

44. Center for Traumatic Brain Injury, Kessler Foundation, East Hanover, NJ 07936, USA

45. Translational Developmental Neuroscience Section, Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, 01307 Dresden, Germany

46. Eating Disorders Research and Treatment Center, Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, 01307 Dresden, Germany

47. Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA

48. Department of Psychology, University of Oregon, Eugene, OR 97403, USA

49. Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA

50. Center for Behavior Genetics of Aging, University of California San Diego, La Jolla, CA 92093, USA

51. Center for Autism Research, Kessler Foundation, East Hanover, NJ 07936, USA

52. Department of Pediatrics, Division of Neurology, UCLA Mattel Children’s Hospital, Los Angeles, CA 90095, USA

53. Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA

54. Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Goethe University, 60590 Frankfurt, Germany

55. Hospital Universitari Institut Pere Mata, 43007 Tarragona, Spain

56. Institut d’Investiació Sanitària Pere Virgili-CERCA, Universitat Rovira i Virgili, 43007 Tarragona, Spain

57. Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul 08826, Republic of Korea

58. Department of Biomedicine, University of Bergen, 5007 Bergen, Norway

59. Division of Psychiatry, Haukeland University Hospital, 5021 Bergen, Norway

60. Center for Biobehavioral Health, The Abigail Wexner Research Institute at Nationwide Children’s Hospital, Columbus, OH 43205, USA

61. Section of Pediatrics, The Ohio State University College of Medicine, Columbus, OH 43210, USA

62. Translational Research Centre, University Hospital of Psychiatry and Psychotherapy, University of Bern, 3000 Bern, Switzerland

63. Ethel Percy Andrus Gerontology Center, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA

64. Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA 90089, USA

65. Department of Quantitative & Computational Biology, Dornsife College of Arts & Sciences, University of Southern California, Los Angeles, CA 90089, USA

66. University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, 3000 Bern, Switzerland

67. Clinic of Child and Adolescent Psychiatry, Centre of Psychosocial Medicine, University of Heidelberg, 69120 Heidelberg, Germany

68. Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA

69. National Institute of Mental Health, 250 67 Klecany, Czech Republic

70. Cognitive Health Initiative, Central Clinical School, Monash University, Melbourne, VIC 3800, Australia

71. Department of Neuropsychiatry, Seoul National University Hospital, Seoul 03080, Republic of Korea

72. Department of Psychiatry, Seoul National University College of Medicine, Seoul 03080, Republic of Korea

73. Department of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital, 128 00 Prague, Czech Republic

74. Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, 0424 Oslo, Norway

75. Department of Psychology, University of Oslo, 0373 Oslo, Norway

76. Department of Research, Sunnaas Rehabilitation Hospital, 1450 Nesodden, Norway

77. Department of Life Sciences, College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge UB8 3PH, UK

78. Brain Imaging and Analysis Center, Duke University, Durham, NC 27710, USA

79. National Intrepid Center of Excellence, Walter Reed National Military Medical Center, Bethesda, MD 20814, USA

80. Department of Neuroscience, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA

81. Department of Biological and Medical Psychology, University of Bergen, 5007 Bergen, Norway

82. Institute D’Or for Research and Education (IDOR), São Paulo 04501-000, Brazil

83. Department of Radiation Medicine and Applied Sciences and Psychiatry, University of California San Diego, La Jolla, CA 92093, USA

84. Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, CA 92093, USA

85. Institute for Translational Neuroscience, University of Münster, 48149 Münster, Germany

86. VISN 6 MIRECC, Durham VA, Durham, NC 27705, USA

87. Center of Excellence on Mood Disorders, Louis A Faillace, MD Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA

88. Faculty of Computer Science, Dalhousie University, Halifax, NS B3H 4R2, Canada

89. Department of Neuroscience, The School of Translational Medicine, Alfred Health, Monash University, Melbourne VIC 3004, Australia

90. Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Frankfurt University, 60590 Frankfurt, Germany

91. Department of Psychology, Norwegian University of Science and Technology, 7491 Trondheim, Norway

92. Department of Physical Medicine and Rehabilitation, St Olavs Hospital, Trondheim University Hospital, 7006 Trondheim, Norway

93. NorHEAD—Norwegian Centre for Headache Research, 7491 Trondheim, Norway

94. Department of Electrical and Electronics Engineering, Antalya Bilim University, 07190 Antalya, Turkey

95. Neuroscience Institute & Department of Psychology, Georgia State University, Atlanta, GA 30303, USA

96. WG (Bill) Hefner VA Medical Center, Salisbury, NC 28144, USA

97. Department of Neurobiology & Anatomy, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA

98. VA Mid-Atlantic Mental Illness Research Education and Clinical Center (MA-MIRECC), Durham, NC 27705, USA

99. Cognitive Neuroscience Unit, School of Psychology, Deakin University, Geelong, VIC 3220, Australia

100. Department of Paediatrics, The University of Melbourne, Parkville, VIC 3052, Australia

101. Department of Psychiatry (UPK), University of Basel, 4002 Basel, Switzerland

102. 3rd Faculty of Medicine, Charles University, 100 00 Prague, Czech Republic

103. Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, CA 90292, USA

104. Department of Psychology, Georgia State University, Atlanta, GA 30303, USA

105. Department of Psychiatry, University of British Columbia, Vancouver, BC V6T 1Z4, Canada

106. British Columbia Mental Health and Substance Use Services Research Institute, Vancouver, BC V5Z 1M9, Canada

107. Michael E DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA

108. H Ben Taub Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX 77030, USA

109. Psychiatry and Behavioral Health, Ohio State Wexner Medical Center, Columbus, OH 43210, USA

110. Division of Endocrinology, Emory University School of Medicine, Atlanta, GA 30322, USA

111. Department of Physical Medicine and Rehabilitation, Virginia Commonwealth University, Richmond, VA 23298, USA

112. Richmond Veterans Affairs (VA) Medical Center, Central Virginia VA Health Care System, Richmond, VA 23249, USA

113. KG Jebsen Center for Neurodevelopmental Disorders, University of Oslo, 0372 Oslo, Norway

114. Department of Psychology, Phoenix VA Health Care System, Phoenix, AZ 85012, USA

115. Rocco Ortenzio Neuroimaging Center, Kessler Foundation, East Hanover, NJ 07936, USA

116. Departments of Neurology, Pediatrics, Psychiatry, Radiology, Engineering, and Ophthalmology, University of Southern California, Los Angeles, CA 90089, USA

117. Department of Psychology, Penn State University, State College, PA 16801, USA

118. Department of Neurology, Hershey Medical Center, State College, PA 16801, USA

119. Social Life and Engineering Science Imaging Center, Penn State University, State College, PA 16801, USA

Abstract

Deficits in memory performance have been linked to a wide range of neurological and neuropsychiatric conditions. While many studies have assessed the memory impacts of individual conditions, this study considers a broader perspective by evaluating how memory recall is differentially associated with nine common neuropsychiatric conditions using data drawn from 55 international studies, aggregating 15,883 unique participants aged 15–90. The effects of dementia, mild cognitive impairment, Parkinson’s disease, traumatic brain injury, stroke, depression, attention-deficit/hyperactivity disorder (ADHD), schizophrenia, and bipolar disorder on immediate, short-, and long-delay verbal learning and memory (VLM) scores were estimated relative to matched healthy individuals. Random forest models identified age, years of education, and site as important VLM covariates. A Bayesian harmonization approach was used to isolate and remove site effects. Regression estimated the adjusted association of each clinical group with VLM scores. Memory deficits were strongly associated with dementia and schizophrenia (p < 0.001), while neither depression nor ADHD showed consistent associations with VLM scores (p > 0.05). Differences associated with clinical conditions were larger for longer delayed recall duration items. By comparing VLM across clinical conditions, this study provides a foundation for enhanced diagnostic precision and offers new insights into disease management of comorbid disorders.

Publisher

MDPI AG

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3