Synthesis and Characterisation of CeO2 Coatings on the AZ31 Alloy for Corrosion Protection and In Vitro Biocompatibility of MC3T3-E1 Pre-Osteoblasts

Author:

Benito-Santiago Sandra E.1ORCID,Onofre-Bustamante Edgar1ORCID,Lozano-Puerto Rosa M.2ORCID

Affiliation:

1. Instituto Politécnico Nacional-Centro de Investigación en Ciencia Aplicada y Tecnología Avanzada, Unidad Altamira, Km. 14.5 Carretera Tampico-Puerto Industrial Altamira, Altamira 89600, Mexico

2. Cell-Biomaterial Recognition Laboratory, Department of Cellular and Molecular Biology, Centro de Investigaciones Biológicas Margarita Salas (CIB-MS, CSIC), c/Ramiro de Maeztu 9, 28040 Madrid, Spain

Abstract

The use of bioabsorbable metals as temporary medical implants has attracted considerable research interest as they do not require a second surgical operation for removal after the healing process is completed. However, magnesium (Mg) and its alloys have a degradation rate that is too high in biological environments. Therefore, it must be controlled using various strategies. In this study, an AZ31-Mg-based alloy coated with CeO2 is investigated to analyse the effect of the coating on its corrosion protection and biocompatibility. The AZ31 alloy is anodised with NaOH solution, before coating to stabilise the alloy surface. The CeO2 coating is deposited on anodised AZ31 by chemical conversion treatment. The electrochemical properties of samples are evaluated using electrochemical impedance spectroscopy and cyclic polarisation curves using Hank’s solution. Structural and morphological characterisation of the samples are performed using X-ray diffraction and scanning electron microscopy–energy dispersive X-ray spectroscopy. Additionally, biocompatibility is determined by live/dead assay using MC3T3-E1 pre-osteoblasts. The preliminary results indicate that CeO2 coatings exhibit higher electrochemical properties. Additionally, an increase in the ratio of live/dead cells of the AZ31OH-CeO2 surface is detected, in contrast with AZ31, thus indicating improvement in biocompatibility upon CeO2 coating.

Funder

Consejo Nacional de Ciencia y Tecnología (CONACYT) Science Grant

Instituto Politécnico Nacional

Consejo Superior de Investigaciones Científicas

Spanish Ministry of Science, Innovation and Universities

Publisher

MDPI AG

Subject

General Materials Science,Metals and Alloys

Reference54 articles.

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2. Biodegradable Materials for Bone Repair and Tissue Engineering Applications;Sheikh;Materials,2015

3. Recent advances on the development of magnesium alloys for biodegradable implants;Chen;Acta Biomater.,2014

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5. Salehi, G., Behnamghader, A., and Mozafari, M. (2020). Handbook of Biomaterials Biocompatibility, Elsevier.

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