Novel Biomarkers of Diabetic Kidney Disease

Author:

Rico-Fontalvo Jorge12ORCID,Aroca-Martínez Gustavo12,Daza-Arnedo Rodrigo1,Cabrales José3ORCID,Rodríguez-Yanez Tomás4ORCID,Cardona-Blanco María1,Montejo-Hernández Juan1,Rodelo Barrios Dairo5ORCID,Patiño-Patiño Jhonny6,Osorio Rodríguez Elber7ORCID

Affiliation:

1. Nephrologist, Colombian Association of Nephrology, Bogota 110221, Colombia

2. Faculty of Medicine, Universidad Simón Bolívar, Barranquilla 080002, Colombia

3. Nephrology Fellow, Stanford University School of Medicine, Palo Alto, CA 94305, USA

4. Internal Medicine, Universidad de Cartagena, Cartagena 130001, Colombia

5. Graduate Student in Critical Medicine and Intensive Care, Simon Bolivar University, Barranquilla 080002, Colombia

6. Independent Researcher, Barranquilla 080002, Colombia

7. Group of Intensive Care and Comprehensive Care (GRIMICI), Barranquilla 080002, Colombia

Abstract

Diabetic kidney disease (DKD) is a highly prevalent condition worldwide. It represents one of the most common complications arising from diabetes mellitus (DM) and is the leading cause of end-stage kidney disease (ESKD). Its development involves three fundamental components: the hemodynamic, metabolic, and inflammatory axes. Clinically, persistent albuminuria in association with a progressive decline in glomerular filtration rate (GFR) defines this disease. However, as these alterations are not specific to DKD, there is a need to discuss novel biomarkers arising from its pathogenesis which may aid in the diagnosis, follow-up, therapeutic response, and prognosis of the disease.

Publisher

MDPI AG

Subject

Molecular Biology,Biochemistry

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