The Contribution of Type 2 Diabetes to Parkinson’s Disease Aetiology

Author:

Ribarič Samo1

Affiliation:

1. Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Zaloška 4, 1000 Ljubljana, Slovenia

Abstract

Type 2 diabetes (T2D) and Parkinson’s disease (PD) are chronic disorders that have a significant health impact on a global scale. Epidemiological, preclinical, and clinical research underpins the assumption that insulin resistance and chronic inflammation contribute to the overlapping aetiologies of T2D and PD. This narrative review summarises the recent evidence on the contribution of T2D to the initiation and progression of PD brain pathology. It also briefly discusses the rationale and potential of alternative pharmacological interventions for PD treatment.

Funder

Slovenian Research and Innovation Agency

Publisher

MDPI AG

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1. Chemokine CX3CL1 (Fractalkine) Signaling and Diabetic Encephalopathy;International Journal of Molecular Sciences;2024-07-09

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