The Inhibition of NS2B/NS3 Protease: A New Therapeutic Opportunity to Treat Dengue and Zika Virus Infection

Author:

Starvaggi Josè1,Previti Santo1ORCID,Zappalà Maria1ORCID,Ettari Roberta1ORCID

Affiliation:

1. Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d’Alcontres 31, 98166 Messina, Italy

Abstract

In the global pandemic scenario, dengue and zika viruses (DENV and ZIKV, respectively), both mosquito-borne members of the flaviviridae family, represent a serious health problem, and considering the absence of specific antiviral drugs and available vaccines, there is a dire need to identify new targets to treat these types of viral infections. Within this drug discovery process, the protease NS2B/NS3 is considered the primary target for the development of novel anti-flavivirus drugs. The NS2B/NS3 is a serine protease that has a dual function both in the viral replication process and in the elusion of the innate immunity. To date, two main classes of NS2B/NS3 of DENV and ZIKV protease inhibitors have been discovered: those that bind to the orthosteric site and those that act at the allosteric site. Therefore, this perspective article aims to discuss the main features of the use of the most potent NS2B/NS3 inhibitors and their impact at the social level.

Publisher

MDPI AG

Reference79 articles.

1. World Health Organization (2023, December 15). Dengue and Severe Dengue, Available online: https://www.who.int/news-room/fact-sheets/detail/dengue-and-severe-dengue.

2. Peptide derivatives as inhibitors of NS2B-NS3 protease from Dengue, West Nile, and Zika flaviviruses;Bioorg. Med. Chem.,2019

3. Current understanding of the pathogenesis of Dengue virus infection;Bhatt;Curr. Microbiol.,2021

4. World Health Organization (2023, December 15). Zika Virus, Available online: https://www.who.int/news-room/fact-sheets/detail/zika-virus.

5. Molecular mechanisms of Zika virus pathogenesis: An update;Bhagat;Indian J. Med. Res.,2021

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