Abstract
(Peri)centromeric repetitive sequences and, more specifically, satellite DNA (satDNA) sequences, constitute a major human genomic component. SatDNA sequences can vary on a large number of features, including nucleotide composition, complexity, and abundance. Several satDNA families have been identified and characterized in the human genome through time, albeit at different speeds. Human satDNA families present a high degree of sub-variability, leading to the definition of various subfamilies with different organization and clustered localization. Evolution of satDNA analysis has enabled the progressive characterization of satDNA features. Despite recent advances in the sequencing of centromeric arrays, comprehensive genomic studies to assess their variability are still required to provide accurate and proportional representation of satDNA (peri)centromeric/acrocentric short arm sequences. Approaches combining multiple techniques have been successfully applied and seem to be the path to follow for generating integrated knowledge in the promising field of human satDNA biology.
Funder
Fundação para a Ciência e a Tecnologia, Portugal
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference199 articles.
1. Repeated Sequences in DNA
2. So much’junk’DNA in our genome. In Proceedings of Evolution of Genetic Systems;Ohno;Brookhaven Symp. Biol.,1972
3. The Case for Junk DNA
4. The repetitive DNA content of eukaryotic genomes;López-Flores,2012
5. Alpha satellite DNA biology: finding function in the recesses of the genome
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