Platelet Dynamics in Neurodegenerative Disorders: Investigating the Role of Platelets in Neurological Pathology
-
Published:2024-04-03
Issue:7
Volume:13
Page:2102
-
ISSN:2077-0383
-
Container-title:Journal of Clinical Medicine
-
language:en
-
Short-container-title:JCM
Author:
Cadoni Maria Piera L.1ORCID, Coradduzza Donatella1ORCID, Congiargiu Antonella1ORCID, Sedda Stefania1, Zinellu Angelo1ORCID, Medici Serenella2ORCID, Nivoli Alessandra Matilde34, Carru Ciriaco1ORCID
Affiliation:
1. Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy 2. Department of Chemical, Physical, Mathematical and Natural Sciences, University of Sassari, 07100 Sassari, Italy 3. Department of Medical, Surgical and Experimental Sciences, University of Sassari, 07100 Sassari, Italy 4. Psychiatric Unit Clinic of the University Hospital, 07100 Sassari, Italy
Abstract
Background: Neurological disorders, particularly those associated with aging, pose significant challenges in early diagnosis and treatment. The identification of specific biomarkers, such as platelets (PLTs), has emerged as a promising strategy for early detection and intervention in neurological health. This systematic review aims to explore the intricate relationship between PLT dynamics and neurological health, focusing on their potential role in cognitive functions and the pathogenesis of cognitive disorders. Methods: Adhering to PRISMA guidelines, a comprehensive search strategy was employed in the PubMed and Scholar databases to identify studies on the role of PLTs in neurological disorders published from 2013 to 2023. The search criteria included studies focusing on PLTs as biomarkers in neurological disorders, their dynamics, and their potential in monitoring disease progression and therapy effectiveness. Results: The systematic review included 104 studies, revealing PLTs as crucial biomarkers in neurocognitive disorders, acting as inflammatory mediators. The findings suggest that PLTs share common features with altered neurons, which could be utilised for monitoring disease progression and evaluating the effectiveness of treatments. PLTs are identified as significant biomarkers for detecting neurological disorders in their early stages and understanding the pathological events leading to neuronal death. Conclusions: The systematic review underscores the critical role of PLTs in neurological disorders, highlighting their potential as biomarkers for the early detection and monitoring of disease progression. However, it also emphasises the need for further research to solidify the use of PLTs in neurological disorders, aiming to enhance early diagnosis and intervention strategies.
Reference163 articles.
1. Overview of neurocognitive disorders;McDonald;Focus,2017 2. Strydom, A., Fleisher, M.H., Deb, S., Ring, H., Esralew, L., Dodd, K., al Janab, T., Trollor, J., and Whitwham, S.L. (2016). Neurocognitive Disorders, NADD Press. 3. Search for alzheimer’s disease biomarkers in blood cells: Hypotheses-driven approach;Wojsiat;Biomark. Med.,2017 4. Ageing as a risk factor for neurodegenerative disease;Hou;Nat. Rev. Neurol.,2019 5. Kim, S., Kim, D.K., Jeong, S., and Lee, J. (2022). The common cellular events in the neurodegenerative diseases and the associated role of endoplasmic reticulum stress. Int. J. Mol. Sci., 23.
|
|