The Use of Biomaterials in Three-Dimensional Culturing of Cancer Cells-Reference-Cited by-同舟云学术

The Use of Biomaterials in Three-Dimensional Culturing of Cancer Cells

Published:2023-01-30 Issue:2 Volume:45 Page:1100-1112
ISSN:1467-3045
Container-title:Current Issues in Molecular Biology
language:en
Short-container-title:CIMB

Author:

Hanasti Novia¹,Faridah Lia²³,Fibriani Azzania⁴^ORCID,Wiraswati Hesti Lina²^ORCID,Kusumawaty Diah⁵,Ekawardhani Savira²³^ORCID

Affiliation:

1. Department of Biotechnology, Faculty of Graduate School, University of Padjadjaran, Bandung 54211, SSWJ, Indonesia

2. Department of Biomedical Sciences, Parasitology Division, Faculty of Medicine, University of Padjadjaran, Bandung 54211, SSWJ, Indonesia

3. HSE Laboratory, KST UNPAD, University of Padjadjaran, Bandung 54211, SSWJ, Indonesia

4. Department of School Life Sciences & Technology, Bandung Institute of Technology, Bandung 54211, SSWJ, Indonesia

5. Department of Biology Education, Faculty of Mathematics and Science Education, The Education University, Bandung 54211, SSWJ, Indonesia

Abstract

Cell culture is an important tool in biological research. Most studies use 2D cell culture, but cells grown in 2D cell culture have drawbacks, including limited cell and cell-extracellular matrix interactions, which make it inaccurate to model conditions in vivo. Anticancer drug screening is an important research and development process for developing new drugs. As an experiment to mimic the cancer environment in vivo, several studies have been carried out on 3-dimensional (3D) cell cultures with added biomaterials. The use of hydrogel in 3D culture cells is currently developing. The type of hydrogel used might influence cell morphology, viability, and drug screening outcome. Therefore, this review discusses 3D cell culture research regarding the addition of biomaterials.

Funder

University of Padjadjaran

Riset Kolaborasi Indonesia

Publisher

MDPI AG

Subject

Microbiology (medical),Molecular Biology,General Medicine,Microbiology

Link

https://www.mdpi.com/1467-3045/45/2/73/pdf

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