Dietary Behavior of Spanish Schoolchildren in Relation to the Polygenic Risk of Obesity
-
Published:2023-10-11
Issue:20
Volume:13
Page:11169
-
ISSN:2076-3417
-
Container-title:Applied Sciences
-
language:en
-
Short-container-title:Applied Sciences
Author:
Calderón García Andrea123ORCID, Pedrero Tomé Roberto24, Alaminos-Torres Ana24, Prado Martínez Consuelo25ORCID, Martínez Álvarez Jesús Román12, López Ejeda Noemí124ORCID, Cabañas Armesilla María Dolores2, Marrodán Serrano María Dolores124ORCID
Affiliation:
1. Sociedad Española de Dietética y Ciencias de la Alimentación (SEDCA), 28080 Madrid, Spain 2. Research Group EPINUT (Nutritional Epidemiology), Faculty of Medicine, Complutense University of Madrid, 28040 Madrid, Spain 3. Department of Nursing and Nutrition, Faculty of Biomedical Sciences, European University of Madrid, UEM, Villaviciosa de Odón, 28670 Madrid, Spain 4. Department of Biodiversity, Ecology and Evolution, Faculty of Biology, Complutense University of Madrid, 28040 Madrid, Spain 5. Department of Biology, Faculty of Sciences, Universidad Autónoma de Madrid, 28049 Madrid, Spain
Abstract
Several precedents support an association between single nucleotide genetic polymorphisms (SNPs), the obese phenotype, and eating behavior in the infant-juvenile population. This study aims to study this aspect in depth, analyzing the eating behavior of a sample of schoolchildren from Madrid in regard to their genetic predisposition to obesity. A total of 258 schoolchildren, aged 6 to 16 years, were evaluated through the Children’s Eating Behaviour Questionnaire (CEBQ) and the genotyping of 32 SNPs. Associations were observed between the total genetic risk score and eating behaviors related to emotional eating and food responsiveness. Individually, different SNPs were associated with eating behaviors, primarily those related to pro-eating behaviors or increased risk of developing obesity. However, diverse results are obtained, depending on the SNP. These results highlighted the strongest associations between the rs1801725 SNP risk allele (CASR) and increased enjoyment of food by 1846-fold. Likewise, the satiety response was associated with SNP rs11676272 (ADCY3) 2.39 and SNP rs7566605 (INSIG2), increasing this response by 2.39 and 1.63 times, respectively. Emotional anti-ingesting behaviors were inversely associated with SNP rs1421085 (FTO) and SNP rs987237 (TFAP2B). In contrast, SNP rs55915917 (CRHR1) increased the risk of these behaviors. SNPs rs4788099 (SH2B1), rs6857 (NECTIN2), and rs180172 (ADCY3) were associated with slow feeding. In conclusion, associations were found between most of the analyzed SNPs and the CEBQ items. This suggests that feeding behavior exists as a mediator between genotype and obesity phenotype, beginning in childhood.
Funder
BANCO DE SANTANDER
Subject
Fluid Flow and Transfer Processes,Computer Science Applications,Process Chemistry and Technology,General Engineering,Instrumentation,General Materials Science
Reference40 articles.
1. Dietary Patterns and Childhood Obesity Risk: A Systematic Review;Liberali;Child Obes.,2020 2. Vesnina, A., Prosekov, A., Kozlova, O., and Atuchin, V. (2020). Genes and Eating Preferences, Their Roles in Personalized Nutrition. Genes, 11. 3. Comuzzie, A.G., Cole, S.A., Laston, S.L., Voruganti, V.S., Haack, K., Gibbs, R.A., and Butte, N.F. (2012). Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. PLoS ONE, 12. 4. Jääskeläinen, A., Schwab, U., Kolehmainen, M., Kaakinen, M., Savolainen, M.J., Froguel, P., Cauchi, S., Järvelin, M.-R., and Laitinen, J. (2013). Meal frequencies modify the effect of common genetic variants on body mass index in adolescents of the northern Finland birth cohort 1986. PLoS ONE, 8. 5. Behavioral Susceptibility Theory: Professor Jane Wardle and the role of appetite in the genetic risk of obesity;Llewellyn;Curr. Obes. Rep.,2017
|
|