Lymphedema Surgical Treatment Using BioBridgeTM: A Preliminary Experience

Author:

Cè Maurizio1ORCID,Menozzi Andrea2,Soresina Massimo2,Giardini Denisa2,Martinenghi Carlo3,Cellina Michaela4ORCID

Affiliation:

1. Postgraduation School in Radiodiagnostics, Università Degli Studi di Milano, Via Festa del Perdono, 7, 20122 Milan, Italy

2. Casa di Cura La Madonnina, Via Quadronno 29, 20122 Milan, Italy

3. Radiology Department, IRCCS San Raffaele Hospital, Via Olgettina 60, 20123 Milan, Italy

4. Radiology Department, Fatebenefratelli Hospital, ASST Fatebenefratelli Sacco, Piazza Principessa Clotilde 3, 20121 Milano, Italy

Abstract

Lymphedema treatment has traditionally been based on conservative therapies. In recent years, the introduction of two microsurgical techniques—venolymphatic anastomoses and lymph-node transplantation—have revolutionized the therapeutic approach to this disease. However, these surgical techniques only provide a partial volume reduction, and thus, they require further improvement. A new device called BioBridgeTM, an implantable biocompatible and biodegradable mesh, made up of aligned nanofibrillar collagen scaffolds that mimic the collagen matrix, could significantly improve the benefits of these surgical strategies, favoring lymphatic regeneration. In this article, we describe our experience with three patients affected by primary lymphedema, two treated with a lymph-node transplant, and one with venolymphatic anastomosis. All interventions involved the placement of nanocollagen scaffolds. With each patient, non-contrast magnetic resonance lymphography was performed for surgical planning and there was an imaging and a clinical follow-up at 1 year. All patients showed a significant reduction in the affected areas with the demonstration of new lymphatic vessels at MR imaging follow-up. This was a preliminary experience, and it showed the potential benefit of positioning nonfibrillar scaffolds in combination with other microsurgical therapies for lymphedema.

Publisher

MDPI AG

Subject

Fluid Flow and Transfer Processes,Computer Science Applications,Process Chemistry and Technology,General Engineering,Instrumentation,General Materials Science

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