Molar Distalization by Clear Aligners with Sequential Distalization Protocol: A Systematic Review and Meta-Analysis

Author:

Shen Christie1,Park Tiffany H.2,Chung Chun-Hsi1,Li Chenshuang1ORCID

Affiliation:

1. Department of Orthodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

2. School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

Abstract

Introduction: With the popularity of clear aligners, the sequential distalization protocol has been more commonly used for molar distalization. However, the amount of molar distalization that can be achieved, as well as the accompanying side effects on the sagittal dimension, are unclear. Methods: Registered with PROSPERO (CRD42023447211), relevant original studies were screened from seven databases (MEDLINE [PubMed], EBSCOhost, Web of Science, Elsevier [SCOPUS], Cochrane, LILACS [Latin American and Caribbean Health Sciences Literature], and Google Scholar) supplemented by a manual search of the references of the full-reading manuscripts by two investigators independently. A risk of bias assessment was conducted, relevant data were extracted, and meta-analysis was performed using RStudio. Results: After the screening, 13 articles (11 involving maxillary distalization, two involving mandibular distalization) met the inclusion criteria. All studies had a high or medium risk of bias. The meta-analysis revealed that the maxillary first molar (U6) mesiobuccal cusp was distalized 2.07 mm [1.38 mm, 2.77 mm] based on the post-distalization dental model superimposition, and the U6 crown was distalized 2.00 mm [0.77 mm, 3.24 mm] based on the post-treatment lateral cephalometric evaluation. However, the U6 mesiobuccal root showed less distalization of 1.13 mm [−1.34 mm, 3.60 mm], indicating crown distal tipping, which was validated by meta-analysis (U6-PP angle: 2.19° [1.06°, 3.33°]). In addition, intra-arch anchorage loss was observed at the post-distalization time point (U1 protrusion: 0.39 mm [0.27 mm, 0.51 mm]), which was corrected at the post-treatment time point (incisal edge-PTV distance: −1.50 mm [−2.61 mm, −0.39 mm]). Conclusion: About 2 mm maxillary molar distalization can be achieved with the sequential distalization protocol, accompanied by slight molar crown distal tipping. Additional studies on this topic are needed due to the high risk of bias in currently available studies.

Funder

American Association of Orthodontists Foundation (AAOF) Orthodontic Faculty Development Fellowship Award

International Orthodontic Foundation (IOF) Young Research Grant

American Academy of Periodontology Foundation

Dr. Colin Richman And Family Perio.–Ortho. Interface Award

University of Pennsylvania School of Dental Medicine Joseph and Josephine Rabinowitz Award for Excellence in Research

J. Henry O’Hern Jr. Pilot Grant from the Department of Orthodontics, University of Pennsylvania School of Dental Medicine

American Association for Dental, Oral, and Craniofacial Research Anne D. Haffajee Fellowship

U.S. National Institutes of Health/National Institute of Dental and Craniofacial Research

AAOF Research Aid Award

Publisher

MDPI AG

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