Manipulation, Sampling and Inactivation of the SARS-CoV-2 Virus Using Nonuniform Electric Fields on Micro-Fabricated Platforms: A Review

Author:

Mantri Devashish1ORCID,Wymenga Luutzen2,van Turnhout Jan3,van Zeijl Henk2,Zhang Guoqi2

Affiliation:

1. Department Biomedical Engineering, Delft University of Technology, 2628 CD Delft, The Netherlands

2. Department Microelectronics, Delft University of Technology, 2628 CD Delft, The Netherlands

3. Department Material Science Engineering, Delft University of Technology, 2628 CD Delft, The Netherlands

Abstract

Micro-devices that use electric fields to trap, analyze and inactivate micro-organisms vary in concept, design and application. The application of electric fields to manipulate and inactivate bacteria and single-celled organisms has been described extensively in the literature. By contrast, the effect of such fields on viruses is not well understood. This review explores the possibility of using existing methods for manipulating and inactivating larger viruses and bacteria, for smaller viruses, such as SARS-CoV-2. It also provides an overview of the theoretical background. The findings may be used to implement new ideas and frame experimental parameters that optimize the manipulation, sampling and inactivation of SARS-CoV-2 electrically.

Publisher

MDPI AG

Subject

Electrical and Electronic Engineering,Mechanical Engineering,Control and Systems Engineering

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