Neuroprotective Roles of the Biliverdin Reductase-A/Bilirubin Axis in the Brain

Author:

Paul Bindu D.1234ORCID,Pieper Andrew A.5678910

Affiliation:

1. Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

2. The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

3. Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

4. Lieber Institute for Brain Development, Baltimore, MD 21205, USA

5. Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44106, USA

6. Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA

7. Geriatric Psychiatry, GRECC, Louis Stokes Cleveland VA Medical Center, Cleveland, OH 44106, USA

8. Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA

9. Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA

10. Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA

Abstract

Biliverdin reductase-A (BVRA) is a multi-functional enzyme with a multitude of important roles in physiologic redox homeostasis. Classically, BVRA is well known for converting the heme metabolite biliverdin to bilirubin, which is a potent antioxidant in both the periphery and the brain. However, BVRA additionally participates in many neuroprotective signaling cascades in the brain that preserve cognition. Here, we review the neuroprotective roles of BVRA and bilirubin in the brain, which together constitute a BVRA/bilirubin axis that influences healthy aging and cognitive function.

Funder

American Heart Association and Paul Allen Foundation

NIH NIDA

Solve-ME foundation

Johns Hopkins University

The Valour Foundation

Case Western Reserve University

Translational Psychiatry and the University Hospitals

Department of Veterans Affairs Merit Award

Elizabeth Ring Mather and William Gwinn Mather Fund

S. Livingston Samuel Mather Trust

G.R. Lincoln Family Foundation

Wick Foundation

Leonard Krieger Fund of the Cleveland Foundation

Maxine and Lester Stoller Parkinson’s Research Fund

Louis Stokes VA Medical Center resources and facilities

Publisher

MDPI AG

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