Therapeutic Effects of Stimulating the Melanocortin Pathway in Regulating Ocular Inflammation and Cell Death-Reference-Cited by-同舟云学术

Therapeutic Effects of Stimulating the Melanocortin Pathway in Regulating Ocular Inflammation and Cell Death

Published:2024-01-31 Issue:2 Volume:14 Page:169
ISSN:2218-273X
Container-title:Biomolecules
language:en
Short-container-title:Biomolecules

Author:

Wang Shudan¹²,Kahale Francesca¹^ORCID,Naderi Amirreza¹,Surico Pier¹^ORCID,Yin Jia¹^ORCID,Dohlman Thomas¹,Chen Yihe¹^ORCID,Dana Reza¹^ORCID

Affiliation:

1. Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA

2. Eye Hospital, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China

Abstract

Alpha-melanocyte-stimulating hormone (α-MSH) and its binding receptors (the melanocortin receptors) play important roles in maintaining ocular tissue integrity and immune homeostasis. Particularly extensive studies have demonstrated the biological functions of α-MSH in both immunoregulation and cyto-protection. This review summarizes the current knowledge of both the physiological and pathological roles of α-MSH and its receptors in the eye. We focus on recent developments in the biology of α-MSH and the relevant clinical implications in treating ocular diseases.

Funder

National Eye Institute

Department of Defense

Publisher

MDPI AG

Subject

Molecular Biology,Biochemistry

Link

https://www.mdpi.com/2218-273X/14/2/169/pdf

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