Modelling 3D Tumour Microenvironment In Vivo: A Tool to Predict Cancer Fate-Reference-Cited by-同舟云学术

Modelling 3D Tumour Microenvironment In Vivo: A Tool to Predict Cancer Fate

Published:2023-11-14 Issue:11 Volume:45 Page:9076-9083
ISSN:1467-3045
Container-title:Current Issues in Molecular Biology
language:en
Short-container-title:CIMB

Author:

Marines Johanna¹²,Lorenzini Francesca¹^ORCID,Kissa Karima³,Fontenille Laura¹

Affiliation:

1. AZELEAD, 377 rue du Pr Blayac, 34080 Montpellier, France

2. Molecular Basis of Inflammation Laboratory, Institut de Génétique Humaine, CNRS, Université de Montpellier, 34090 Montpellier, France

3. VBIC, INSERM U1047, Université de Montpellier, 34090 Montpellier, France

Abstract

Recently, many studies demonstrated the fundamental role of the tumour microenvironment (TME) in cancer progression. Here, we describe a method to visualize in 3D the behaviour of tumours in zebrafish embryos. We highlight two major actors of the TME, macrophages and vessels. This valuable tool is transposable to Patient-Derived Xenograft imaging in order to predict the fate of malignant tumours according to the dynamics of their TME.

Funder

NEUcrest-ITN Project

Agence Nationale de Recherche Technologie

AZELEAD

Publisher

MDPI AG

Subject

Microbiology (medical),Molecular Biology,General Medicine,Microbiology

Link

https://www.mdpi.com/1467-3045/45/11/569/pdf

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