Neuroinflammation in the Evolution of Motor Function in Stroke and Trauma Patients: Treatment and Potential Biomarkers
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Published:2023-10-25
Issue:11
Volume:45
Page:8552-8585
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ISSN:1467-3045
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Container-title:Current Issues in Molecular Biology
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language:en
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Short-container-title:CIMB
Author:
Larrea Ane12ORCID, Elexpe Ane1, Díez-Martín Eguzkiñe13ORCID, Torrecilla María2, Astigarraga Egoitz1ORCID, Barreda-Gómez Gabriel1ORCID
Affiliation:
1. Research and Development Division, IMG Pharma Biotech, 48170 Zamudio, Spain 2. Department of Pharmacology, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, 48940 Leioa, Spain 3. Department of Immunology, Microbiology and Parasitology, Faculty of Science and Technology, University of the Basque Country UPV/EHU, 48940 Leioa, Spain
Abstract
Neuroinflammation has a significant impact on different pathologies, such as stroke or spinal cord injury, intervening in their pathophysiology: expansion, progression, and resolution. Neuroinflammation involves oxidative stress, damage, and cell death, playing an important role in neuroplasticity and motor dysfunction by affecting the neuronal connection responsible for motor control. The diagnosis of this pathology is performed using neuroimaging techniques and molecular diagnostics based on identifying and measuring signaling molecules or specific markers. In parallel, new therapeutic targets are being investigated via the use of bionanomaterials and electrostimulation to modulate the neuroinflammatory response. These novel diagnostic and therapeutic strategies have the potential to facilitate the development of anticipatory patterns and deliver the most beneficial treatment to improve patients’ quality of life and directly impact their motor skills. However, important challenges remain to be solved. Hence, the goal of this study was to review the implication of neuroinflammation in the evolution of motor function in stroke and trauma patients, with a particular focus on novel methods and potential biomarkers to aid clinicians in diagnosis, treatment, and therapy. A specific analysis of the strengths, weaknesses, threats, and opportunities was conducted, highlighting the key challenges to be faced in the coming years.
Funder
Basque Government through funding from the BIKAINTEK program The University of the Basque Country through the PIF Industrial program
Subject
Microbiology (medical),Molecular Biology,General Medicine,Microbiology
Reference271 articles.
1. Breda, C.N.d.S., Davanzo, G.G., Basso, P.J., Saraiva Câmara, N.O., and Moraes-Vieira, P.M.M. (2019). Mitochondria as Central Hub of the Immune System. Redox Biol., 26. 2. Lukacova, N., Kisucka, A., Bimbova, K.K., Bacova, M., Ileninova, M., Kuruc, T., and Galik, J. (2021). Glial-Neuronal Interactions in Pathogenesis and Treatment of Spinal Cord Injury. Int. J. Mol. Sci., 22. 3. From Basics to Clinical: A Comprehensive Review on Spinal Cord Injury;Silva;Prog. Neurobiol.,2014 4. Heterogeneity of Reactive Astrocytes;Anderson;Neurosci. Lett.,2014 5. The Science of Stroke: Mechanisms in Search of Treatments;Moskowitz;Neuron,2010
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