Affiliation:
1. The Wistar Institute, Philadelphia, PA 19104, USA
2. Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy
Abstract
Epstein–Barr Virus (EBV) is a human gamma-herpesvirus that is widespread worldwide. To this day, about 200,000 cancer cases per year are attributed to EBV infection. EBV is capable of infecting both B cells and epithelial cells. Upon entry, viral DNA reaches the nucleus and undergoes a process of circularization and chromatinization and establishes a latent lifelong infection in host cells. There are different types of latency all characterized by different expressions of latent viral genes correlated with a different three-dimensional architecture of the viral genome. There are multiple factors involved in the regulation and maintenance of this three-dimensional organization, such as CTCF, PARP1, MYC and Nuclear Lamina, emphasizing its central role in latency maintenance.
Funder
National Institute of Allergy and Infectious Diseases
National Institute of General Medical Sciences
National Cancer Institute
Subject
Virology,Infectious Diseases
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