Effect of a 12-Week Polyphenol Rutin Intervention on Markers of Pancreatic β-Cell Function and Gut Microbiota in Adults with Overweight without Diabetes

Author:

Mathrani Akarsh12ORCID,Yip Wilson123,Sequeira-Bisson Ivana R.123ORCID,Barnett Daniel4,Stevenson Oliver4,Taylor Michael W.12,Poppitt Sally D.1235ORCID

Affiliation:

1. School of Biological Sciences, University of Auckland, Auckland 1010, New Zealand

2. High-Value Nutrition National Science Challenge, Auckland 1010, New Zealand

3. Human Nutrition Unit, University of Auckland, Auckland 1024, New Zealand

4. Department of Statistics, University of Auckland, Auckland 1010, New Zealand

5. Department of Medicine, University of Auckland, Auckland 1010, New Zealand

Abstract

Supplementation with prebiotic polyphenol rutin is a potential dietary therapy for type 2 diabetes prevention in adults with obesity, based on previous glycaemic improvement in transgenic mouse models. Gut microbiota are hypothesised to underpin these effects. We investigated the effect of rutin supplementation on pancreatic β-cell function measured as C-peptide/glucose ratio, and 16S rRNA gene-based gut microbiota profiles, in a cohort of individuals with overweight plus normoglycaemia or prediabetes. Eighty-seven participants were enrolled, aged 18–65 years with BMI of 23–35 kg/m2. This was a 12-week double-blind randomised controlled trial (RCT), with 3 treatments comprising (i) placebo control, (ii) 500 mg/day encapsulated rutin, and (iii) 500 mg/day rutin-supplemented yoghurt. A 2-h oral glucose tolerance test (OGTT) was performed at baseline and at the end of the trial, with faecal samples also collected. Compliance with treatment was high (~90%), but rutin in both capsule and dietary format did not alter pancreatic β-cell response to OGTT over 12 weeks. Gut bacterial community composition also did not significantly change, with Firmicutes dominating irrespective of treatment. Fasting plasma glucose negatively correlated with the abundance of the butyrate producer Roseburia inulinivorans, known for its anti-inflammatory capacity. This is the first RCT to investigate postprandial pancreatic β-cell function in response to rutin supplementation.

Funder

High-Value Nutrition National Science Challenge, New Zealand

Publisher

MDPI AG

Subject

Food Science,Nutrition and Dietetics

Reference105 articles.

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2. (2022, October 31). International Diabetes Federation. Diabetes Atlas. 2019. Available online: https://diabetesatlas.org/.

3. Diabetes and its drivers: The largest epidemic in human history?;Zimmet;Clin. Diabetes Endocrinol.,2017

4. WHO (2022, October 31). Diabetes: Fact Sheet. Available online: https://www.who.int/news-room/fact-sheets/detail/diabetes.

5. Obesity, insulin resistance, and type 2 diabetes: Associations and therapeutic implications;Wondmkun;Diabetes Metab. Syndr. Obes.,2020

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