Synthesis and Evaluation of the (S)-BINAM Derivatives as Fluorescent Enantioselective Detectors

Abstract

Pd(0)-catalyzed amination was employed for the synthesis of a new family of (S)-1,1′-bianaphthalene-2,2′-diamine derivatives possessing additional chiral and fluorophore substituents. The Compounds thus obtained were tested as potential detectors of seven amino alcohols, and some of them were found to be able to recognize individual enantiomers of certain amino alcohols by specific changes of their emission spectra in the presence of these analytes. A pronounced dependence of the detecting abilities on the nature of the substituents in the (S)-BINAM derivatives was observed.