Protective Effects of L-2-Oxothiazolidine-4-Carboxylate during Isoproterenol-Induced Myocardial Infarction in Rats: In Vivo Study-Reference-Cited by-同舟云学术

Protective Effects of L-2-Oxothiazolidine-4-Carboxylate during Isoproterenol-Induced Myocardial Infarction in Rats: In Vivo Study

Published:2022-09-21 Issue:10 Volume:12 Page:1466
ISSN:2075-1729
Container-title:Life
language:en
Short-container-title:Life

Author:

Angelovski Marija¹,Hadzi-Petrushev Nikola¹^ORCID,Atanasov Dino¹,Nikodinovski Aleksandar²,Mitrokhin Vadim³,Avtanski Dimiter⁴^ORCID,Mladenov Mitko¹³^ORCID

Affiliation:

1. Institute of Biology, Faculty of Natural Sciences and Mathematics, Ss. Cyril and Methodius University in Skopje, 1000 Skopje, North Macedonia

2. Institute for Preclinical and Clinical Pharmacology and Toxicology, Medical Faculty, Ss. Cyril and Methodius University in Skopje, 1000 Skopje, North Macedonia

3. Department of Fundamental and Applied Physiology, Russian National Research Medical University, 117997 Moscow, Russia

4. Friedman Diabetes Institute, Lenox Hill Hospital, Northwell Health, 110 E 59th Street, New York, NY 10022, USA

Abstract

This study aimed to evaluate the cardioprotective effects of L-2-oxothiazolidine-4-carboxylate (OTC) against isoproterenol (ISO)-induced acute myocardial infarction (MI) in rats. Results demonstrated that OTC treatments inhibited ISO-induced oxidative damage, suppressed lipid peroxidation, and increased superoxide dismutase and catalase activity in the hearts of the treated rats compared to those of the untreated controls. The ISO-related NF-κB activation was reduced due to the OTC treatment, and lower degrees of inflammatory cell infiltration and necrosis in the hearts were observed. In summary, OTC treatments exerted cardioprotective effects against MI in vivo, mainly due to enhancing cardiac antioxidant activity.

Funder

Faculty of Natural Sciences and Mathematics in Skopje

Publisher

MDPI AG

Subject

Paleontology,Space and Planetary Science,General Biochemistry, Genetics and Molecular Biology,Ecology, Evolution, Behavior and Systematics

Link

https://www.mdpi.com/2075-1729/12/10/1466/pdf

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