Multi-Level Regulatory Interactions between NF-κB and the Pluripotency Factor Lin28

Author:

Mills William T.,Nassar Noor N.,Ravindra Deepa,Li Xinbei,Meffert Mollie K.ORCID

Abstract

An appreciation for the complex interactions between the NF-κB transcription factor and the Lin28 RNA binding protein/let-7 microRNA pathways has grown substantially over the past decade. Both the NF-κB and Lin28/let-7 pathways are master regulators impacting cell survival, growth and proliferation, and an understanding of how interfaces between these pathways participate in governing pluripotency, progenitor differentiation, and neuroplastic responses remains an emerging area of research. In this review, we provide a concise summary of the respective pathways and focus on the function of signaling interactions at both the transcriptional and post-transcriptional levels. Regulatory loops capable of providing both reinforcing and extinguishing feedback have been described. We highlight convergent findings in disparate biological systems and indicate future directions for investigation.

Funder

National Institute of Neurological Disorders and Stroke

National Institute of Mental Health

Publisher

MDPI AG

Subject

General Medicine

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