1,4-Bis(2-((1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethyl)piperazine-Reference-Cited by-同舟云学术

1,4-Bis(2-((1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethyl)piperazine

Published:2024-02-28 Issue:1 Volume:2024 Page:M1780
ISSN:1422-8599
Container-title:Molbank
language:en
Short-container-title:Molbank

Author:

Li-Zhulanov Nikolai S.¹^ORCID,Rogachev Artem D.¹^ORCID,Gatilov Yuri V.¹,Volcho Konstantin P.¹^ORCID,Salakhutdinov Nariman F.¹

Affiliation:

1. N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Lavrentiev Ave., 9, 630090 Novosibirsk, Russia

Abstract

The reaction of (−)-nopol mesylate with piperazine in acetonitrile under reflux, afforded symmetric 1,4-bis(2-((1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethyl)piperazine in a good yield. The compound was fully characterized and its structure was confirmed using X-ray diffraction analysis.

Funder

Russian Science Foundation

Publisher

MDPI AG

Link

https://www.mdpi.com/1422-8599/2024/1/M1780/pdf

Reference11 articles.

1. Zielińska-Błajet, M., and Feder-Kubis, J. (2020). Monoterpenes and Their Derivatives—Recent Development in Biological and Medical Applications. Int. J. Mol. Sci., 21.

2. Monoterpenes as a renewable source of biologically active compounds;Salakhutdinov;Pure Appl. Chem.,2017

3. Li-Zhulanov, N.S., Zaikova, N.P., Sari, S., Gülmez, D., Sabuncuoğlu, S., Ozadali-Sari, K., Arikan-Akdagli, S., Nefedov, A.A., Rybalova, T.V., and Volcho, K.P. (2023). Rational Design of New Monoterpene-Containing Azoles and Their Antifungal Activity. Antibiotics, 12.

4. Piperazine derivatives for therapeutic use: A patent review (2010–present);Rathi;Expert Opin. Ther. Pat.,2016

5. Piperazine scaffold: A remarkable tool in generation of diverse pharmacological agents;Shaquiquzzaman;Eur. J. Med. Chem.,2015