Affiliation:
1. Department of Electrical Engineering and Information Technology, Technical University Dortmund, Friedrich-Wöhler-Weg 4, 44227 Dortmund, Germany
Abstract
The use of surface plasmon resonance sensors allows for the fabrication of highly sensitive, label-free analytical devices. This contribution reports on a grating coupler to enable surface plasmon resonance studies using silver on silicon oxide technology to build long-term stable plasmonic structures for biological molecule sensing. The structural parameters were simulated and the corresponding simulation model was optimized based on the experimental results to improve its reliability. Based on the model, optimized grating nanostructures were fabricated on an oxidized silicon wafer with different structural parameters and characterized using a dedicated optical setup and scanning electron microscopy. The combined theoretical and experimental results show that the most relevant refractive index range for biological samples from 1.32–1.46 may conveniently be covered with a highest sensitivity of 128.85°/RIU.
Funder
Erasmus Mundus LEADERS (leading mobility between Europe and Asia in developing engineering education and research) program
Subject
Electrical and Electronic Engineering,Biochemistry,Instrumentation,Atomic and Molecular Physics, and Optics,Analytical Chemistry
Reference43 articles.
1. Miyazaki, C.M., Shimizu, F.M., and Ferreira, M. (2017). Nanocharacterization Techniques, Elsevier.
2. Enzyme kinetic assays with surface plasmon resonance (BIAcore) based on competition between enzyme and creatinine antibody;Behrsing;Biosens. Bioelectron.,2000
3. Surface plasmon resonance (SPR) analysis of binding interactions of proteins in inner-ear sensory epithelia;Drescher;Methods Mol. Biol.,2009
4. Plasmon-waveguide resonance studies of ligand binding to integral proteins in membrane fragments derived from bacterial and mammalian cells;Salamon;Anal. Biochem.,2009
5. Investigation of biological cell-protein interactions using SPR sensor through laser scanning confocal imaging-surface plasmon resonance system;Zhang;Spectrochim. Acta A Mol. Biomol. Spectrosc.,2014
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献