Author:
Fan Yaqin,Wang Cong,Wang Liping,Chairoungdua Arthit,Piyachaturawat Pawinee,Fu Peng,Zhu Weiming
Abstract
Two new ansamycins, trienomycins H (1) and I (2), together with the known trienomycinol (3), were isolated from the fermentation broth of the deep-sea-derived bacterium Ochrobactrum sp. OUCMDZ-2164. Their structures, including their absolute configurations, were elucidated based on spectroscopic analyses, ECD spectra, and Marfey’s method. Compound 1 exhibited cytotoxic effects on A549 and K562 cell lines with IC50 values of 15 and 23 μM, respectively.
Funder
National Natural Science Foundation of China
Thailand Research Fund
Subject
Drug Discovery,Pharmacology, Toxicology and Pharmaceutics (miscellaneous),Pharmaceutical Science
Cited by
14 articles.
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