Ca2+-Dependent Processes of Innate Immunity in IBD-Reference-Cited by-同舟云学术

Ca2+-Dependent Processes of Innate Immunity in IBD

Published:2024-06-21 Issue:13 Volume:13 Page:1079
ISSN:2073-4409
Container-title:Cells
language:en
Short-container-title:Cells

Author:

Palestra Francesco¹²³^ORCID,Memoli Gina¹²³,Ventrici Annagioia¹²³,Trocchia Marialuisa¹²³,Galdiero Mariarosaria¹²³^ORCID,Varricchi Gilda¹²³⁴^ORCID,Loffredo Stefania¹²³⁴^ORCID

Affiliation:

1. Department of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, Italy

2. Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, 80131 Naples, Italy

3. World Allergy Organization (WAO), Center of Excellence, 80131 Naples, Italy

4. Institute of Experimental Endocrinology and Oncology, National Research Council (CNR), 80131 Naples, Italy

Abstract

IBD is an uncontrolled inflammatory condition of the gastrointestinal tract, which mainly manifests in two forms: ulcerative colitis (UC) and Crohn’s disease (CD). The pathogenesis of IBD appears to be associated with an abnormal response of innate and adaptive immune cells. Innate immunity cells, such as macrophages, mast cells, and granulocytes, can produce proinflammatory (e.g., TNF-α) and oxidative stress (ROS) mediators promoting intestinal damage, and their abnormal responses can induce an imbalance in adaptive immunity, leading to the production of inflammatory cytokines that increase innate immune damage, abate intestinal barrier functions, and aggravate inflammation. Considering that Ca2+ signalling plays a key role in a plethora of cellular functions, this review has the purpose of deepening the potential Ca2+ involvement in IBD pathogenesis.

Publisher

MDPI AG

Link

https://www.mdpi.com/2073-4409/13/13/1079/pdf

Reference61 articles.

1. GBD Inflammatory Bowel Disease Collaborators (2020). The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990–2017: A systematic analysis for the Global Burden of Disease Study 2017. Lancet Gastroenterol. Hepatol., 5, 17–30.

2. Novel approaches in IBD therapy: Targeting the gut microbiota-bile acid axis;Pan;Gut Microbes,2024

3. Intestinal Immune Imbalance is an Alarm in the Development of IBD;Hu;Mediat. Inflamm.,2023

4. Han, X., Ding, S., Jiang, H., and Liu, G. (2021). Roles of Macrophages in the Development and Treatment of Gut Inflammation. Front. Cell Dev. Biol., 9.

5. The Gut Microbiome and Inflammatory Bowel Diseases;Shan;Annu. Rev. Med.,2022