COVID-19 mRNA Vaccine Effectiveness against Elderly Frail People-Reference-Cited by-同舟云学术

COVID-19 mRNA Vaccine Effectiveness against Elderly Frail People

Published:2023-01-19 Issue:2 Volume:59 Page:202
ISSN:1648-9144
Container-title:Medicina
language:en
Short-container-title:Medicina

Author:

Kountouras Jannis¹,Tzitiridou-Chatzopoulou Maria¹²^ORCID,Papaefthymiou Apostolis¹³^ORCID,Chatzopoulos Dimitrios¹,Doulberis Michael¹⁴^ORCID

Affiliation:

1. Second Medical Clinic, School of Medicine, Ippokration Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece

2. Midwifery Department, School of Healthcare Sciences, University of West Macedonia, Koila, 50100 Kozani, Greece

3. Department of Gastroenterology, University Hospital of Larisa, 41110 Larisa, Greece

4. Division of Gastroenterology and Hepatology, Medical University Department, Kantonsspital Aarau, 5001 Aarau, Switzerland

Abstract

The frail, elderly population is often characterized by poor immunogenicity post COVID-19 mRNA vaccination. “Inflame-ageing” and “immune-senescence” are pathogenetic mechanisms that might explain this phenomenon. Complex interplay with cytokines and microbiota is also implicated in this inflammatory cascade. The abovementioned population, although very important from immunologic perspective, has barely been included in the mRNA vaccination clinical trials.

Publisher

MDPI AG

Subject

General Medicine

Link

https://www.mdpi.com/1648-9144/59/2/202/pdf

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