Silent Intruder: Unusual Presentation of Neurocysticercosis in an HIV-Infected Patient from the Far Northern Brazilian Amazon

Author:

Galan Luis E. B.1,Gerolin Letícia R. M.1,Carvalho Tháilla J. M.1,Filardi Eloise T. M.2ORCID,Ramos Dafnin L. S.1,Dantas Domingos S. M.3,Carbonell Roberto C. C.1,Cerni Felipe A.4,Pucca Manuela B.245ORCID

Affiliation:

1. Medical School, Federal University of Roraima, Boa Vista 69310-000, Roraima, Brazil

2. Graduate Program in Bioscience and Biotechnology Applied to Pharmacy, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Campus Araraquara, Araraquara 19060-900, São Paulo, Brazil

3. Programa Doutoral de Bioética da Faculdade de Medicina do Porto, 4050-290 Cidade do Porto, Portugal

4. Graduate Program in Tropical Medicine (PPGMT), State University of Amazonas, Manaus 69850-000, Amazonas, Brazil

5. Department of Clinical Analysis, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Campus Araraquara, Araraquara 19060-900, São Paulo, Brazil

Abstract

Neurocysticercosis, a parasitic infection of the central nervous system (CNS), is a significant public health issue globally, including in Brazil. This article presents a case report of a 44-year-old male patient residing in the rural area of Roraima, the northernmost region of Brazil within the Amazon Forest. The patient, with chronic HIV infection, acquired the Taenia solium helminth, resulting in neurocysticercosis development. Remarkably, the diagnosis of neurocysticercosis was not initially apparent but emerged through meticulous analysis following a motorcycle accident. The absence of seizures, a common clinical manifestation, complicated the diagnostic process, making it an uncommon case of NCC, which may be related to co-infection. As the patient’s condition progressed, multiple complications arose, requiring additional medical attention and interventions. This case underscores the immense challenges faced by healthcare teams in managing neurocysticercosis effectively. It emphasizes the critical need for a comprehensive, multidisciplinary approach to provide optimal care for such complex cases. The study’s findings underscore the importance of raising awareness and implementing improved strategies for tackling neurocysticercosis, particularly in regions where it remains a prevalent concern.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação do Instituto de Biociências

Fundação de Amparo a Pesquisa do Estado do Amazonas

Fundação de Amparo à Pesquisa do Estado de São Paulo

Publisher

MDPI AG

Reference42 articles.

1. Rodríguez-Rivas, R., Flisser, A., Norcia, L.F., Hamamoto Filho, P.T., Bonilla-Aldana, D.K., Rodriguez-Morales, A.J., Carpio, A., Romo, M.L., and Fleury, A. (2022). Neurocysticercosis in Latin America: Current Epidemiological Situation Based on Official Statistics from Four Countries. PLoS Negl. Trop. Dis., 16.

2. Neurocisticercose;Takayanagui;Rev. Soc. Bras. Med. Trop.,2001

3. (2021). PAHO Guideline for Preventive Chemotherapy for the Control of Taenia Solium Taeniasis, Pan American Health Organization.

4. Organização Pan-Americana da Saúde (2022). Diretrizes da OMS para o Manejo da Neurocisticercose por Taenia Solium, OPAS.

5. Reprint of “Neurocysticercosis-Related Mortality in Brazil, 2000–2011: Epidemiology of a Neglected Neurologic Cause of Death”;Ramos;Acta Trop.,2017

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