Relationships between Interleukin 18 -607 C/A and -137 G/C, Osteopontin -9250 C/T Genetic Polymorphisms and Systemic Inflammatory Response Syndrome in Coronary Artery Bypass Graft Surgery

Author:

Köse Serdal Kenan1,Karahilal Bensu2ORCID,Engin Başak2ORCID,Aydoğdu Gülçin3,Yağar Seyhan4,Orhan Kaan567ORCID

Affiliation:

1. Department of Biostatistics, Faculty of Medicine, Ankara University, 06620 Ankara, Turkey

2. Department of Pharmaceutical Toxicology, Gazi University Faculty of Pharmacy, 06330 Ankara, Turkey

3. Department of Biostatistics, Faculty of Medicine, Hitit University, 19030 Çorum, Turkey

4. Department of Anesthesiology, Ankara City Hospital, 06800 Ankara, Turkey

5. Department of Dentomaxillofacial Radiology, Faculty of Dentistry, Ankara University, 06620 Ankara, Turkey

6. Department of Dental and Maxillofacial Radiodiagnostics, Medical University of Lublin, 20-059 Lublin, Poland

7. Medical Design Application and Research Center (MEDITAM), Ankara University, 06620 Ankara, Turkey

Abstract

Background and Objectives: Systemic inflammatory response syndrome (SIRS) is one of the most significant complications after on-pump heart surgery procedures. High cytokine levels have been shown after open-heart surgeries and a genetic predisposition seems to be an important underlying modulatory characteristic for SIRS. To investigate the association between interleukin 18 -607 C/A, interleukin 18 -137 G/C and osteopontin 9250 C/T genetic polymorphisms and SIRS in on-pump CABG patients. Materials and Methods: Two hundred consecutive elective on-pump CABG patients were recruited prospectively to the study. Genomic DNA was extracted from whole blood and genotyping was determined by sequence specific PCR or PCR-RFLP methods for related polymorphisms. Results: SIRS incidence was 60.2%, 38.1%, 18.9% on postoperative day 1, 2 and 3, respectively, in the whole study population. The SIRS rate on the second postoperative day was 13% and 43.4%, respectively, in osteopontin 9250 C/T T allele non-carriers and carriers (p = 0.004). WBC (White Blood Cell) counts were higher on day 2 and 3 in osteopontin 9250 C/T T allele carriers compared to non-carriers (day 2; 12.7 ± 4 vs. 10.5 ± 2.4 (p = 0.015), day 3; 11.8 ± 4 vs. 9.1 ± 4.7 (p = 0.035)). The average ICU stay was 3.1 ± 7.4, 1.28 ± 0.97 for IL 18-137 G/C C allele carriers and non-carriers, respectively (p = 0.003), and in the IL 18-137 G/C C allele carriers, SIRS developed in 42.2% by the second postoperative day whereas the rate was 57.8% in non-carriers (p = 0.025). Conclusions: The current research revealed a possible link between osteopontin 9250 C/T and IL18-137 G/C genetic polymorphism and SIRS and morbidity in on-pump CABG patients.

Publisher

MDPI AG

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