Pulmonary Alveolar Proteinosis and Pregnancy: A Review of the Literature and Case Presentation

Author:

Cimpoca Raptis Brindusa Ana,Panaitescu Anca MariaORCID,Peltecu Gheorghe,Gica NicolaeORCID,Botezatu RaduORCID,Popescu Mihaela RoxanaORCID,Macri Anca,Constantin Ana,Pavel Bogdan

Abstract

Pulmonary Alveolar Proteinosis (PAP) is a rare, usually autoimmune, disease, where surfactant accumulates within alveoli due to decreased clearance, causing dyspnea and hypoxemia. The disease is even more rare in pregnancy; nevertheless, it has been reported in pregnant women and can even appear for the first time during pregnancy as an asthma-like illness. Therefore, awareness is important. Similarly to many autoimmune diseases, it can worsen during pregnancy and postpartum, causing maternal and fetal/neonatal complications. This paper offers a narrative literature review of PAP and pregnancy, while illustrating a case of a pregnant patient with known PAP who developed preeclampsia in the third trimester but had an overall fortunate maternal and neonatal outcome.

Publisher

MDPI AG

Subject

General Medicine

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