Probiotics and Prebiotics Orally Assumed as Disease Modifiers for Stable Mild Atopic Dermatitis: An Italian Real-Life, Multicenter, Retrospective, Observational Study

Author:

Colombo Delia1,Rigoni Corinna2,Cantù Alessandra3,Carnevali Antonello4,Filippetti Rossella5,Franco Tiziana6,Grassi Alessandra7,Loi Camilla8,Mazzotta Annamaria9,Patroi Ivona10,Raone Beatrice11,Tomassini Marco Andrea12,Amoruso Angela13ORCID,Pane Marco13ORCID,Damiani Giovanni1415ORCID

Affiliation:

1. Independent Researcher, Private Practice, Via Livigno 6, 20158 Milan, Italy

2. Independent Researcher, Private Practice, Corso Monteforte 40, 20122 Milan, Italy

3. Independent Researcher, Private Practice, Via Domodossola 9/A, 20145 Milan, Italy

4. Independent Researcher, Private Practice, Str. Colomba Pecorari 32/a, 06134 Perugia, Italy

5. Private Practice, Via Ruspoli 62, 00149 Rome, Italy

6. Independent Researcher, Private Practice, Viao Veio, 04100 Latina, Italy

7. Independent Researcher, Private Practice, Via Coletti 19, 00191 Rome, Italy

8. Independent Researcher, Private Practice, Via X Settembre 1943 7 and 9, 40011 Anzola dell’Emilia, Italy

9. Independent Researcher, Private Practice, Viale di Villa Massimo 48, 00161 Rome, Italy

10. Independent Researcher, Private Practice, Via del Tritone 102, 00187 Rome, Italy

11. Independent Researcher, Private Practice, Via Ruggero Leoncavallo 5, 40137 Bologna, Italy

12. Independent Researcher, Private Practice, Via Ponchielli 30, 06073 Corciano, Italy

13. Independent Researcher, Probiotical Research srl, Via Mattei 3, 28100 Novara, Italy

14. Department of Biomedical, Surgical and Dental Sciences University of Milan, 20122 Milan, Italy

15. Department of Pharmaceutical and Pharmacological Sciences, PhD Degree Program in Pharmacological Sciences, University of Padua, 35122 Padua, Italy

Abstract

The role of the skin–gut axis in atopic dermatitis (AD) remains a subject of debate, limiting non-pharmacological interventions such as probiotics and prebiotics. To improve understanding of their potential as a monotherapy for stable mild cases, we conducted a real-life, multicenter, retrospective observational study in Italy. We administered three selected bacteria (Bifidobacterium animalis subsp. lactis BS01, Lactiplantibacillus plantarum LP14, and Lacticaseibacillus rhamnosus LR05) orally to patients with mild atopic dermatitis without a placebo control group, following up for 12 weeks. Clinical assessments using the Scoring Atopic Dermatitis (SCORAD), Eczema Area and Severity Index (EASI), and Three-Item Severity (TIS) score were conducted on 144 enrolled patients (average age: 25.1 ± 17.6 years). Notably, both pruritus and AD-related lesions (erythema, edema/papules, excoriation) exhibited significant clinical and statistical improvement (p < 0.001) after 12 weeks of exclusive probiotic and prebiotic use. These preliminary results suggest a potential link between the skin–gut microbiome and support the rationale for using specific probiotics and prebiotics in mild AD, even for maintenance, to reduce flares and dysbiosis.

Funder

Funziona s.r.l.

Publisher

MDPI AG

Subject

General Medicine

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. The use of essential oils in atopic dermatitis: a review;Current Medical Research and Opinion;2024-04-25

2. Role of Nutribiotics in Skin Care;Applied Sciences;2024-04-21

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