Subsequent Domino Osteoporotic Vertebral Fractures Adversely Affect Short-Term Health-Related Quality of Life: A Prospective Multicenter Study

Author:

Kusukawa Tomoyuki1,Maruo Keishi1234,Toi Masakazu2,Yamaura Tetsuto56,Hatano Masaru3,Nagao Kazuma67,Oishi Hayato7,Horinouchi Yutaka8,Arizumi Fumihiro1,Kishima Kazuya1,Yoshie Norichika16ORCID,Tachibana Toshiya1

Affiliation:

1. Department of Orthopaedic Surgery, Hyogo Medical University, Nishinomiya 663-8131, Japan

2. Department of Orthopaedic Surgery, Miyoshi Hospital, Miyoshi 778-0005, Japan

3. Department of Orthopaedic Surgery, Daiwa Central Hospital, Osaka 557-0025, Japan

4. Department of Orthopaedic Surgery, Goushi Hospital, Nagasu Nishidori 660-0807, Japan

5. Department of Orthopaedic Surgery, Harima Hospital, Asahi Aioi 678-0031, Japan

6. Department of Orthopaedic Surgery, Osaka Minato Central Hospital, Osaka 552-0003, Japan

7. Department of Orthopaedic Surgery, Takarazuka City Hospital, Takarazuka 665-0827, Japan

8. Department of Orthopaedic Surgery, Sasayama Medical Center, Hyogo Medical University, Tamba-Sasayama 669-2321, Japan

Abstract

Background and Objectives: Conservative treatment is the gold standard for acute osteoporotic vertebral fractures (AOVFs). However, the treatment strategy for multiple AOVFs remains unknown. We conducted a prospective study using magnetic resonance imaging (MRI) to investigate how rapidly subsequent osteoporotic vertebral fractures (OVFs) occur as domino OVFs within 3 months. This study aimed to assess the incidence and impact of domino OVFs on quality of life (QOL) following conservative treatment for initial AOVFs. Materials and Methods: A prospective multicenter cohort study was conducted at eight hospitals. The included patients were those with AOVFs occurring within 3 weeks, aged >60 years, and diagnosed using MRI. All patients were treated conservatively and underwent MRI after 3 months. Subsequent domino OVFs were defined as newly occurring OVFs within 3 months. Patient characteristics, types of conservative treatment, and patient-reported outcomes, including a visual analogue scale (VAS), the Oswestry disability index (ODI), and the Japanese Orthopaedic Association back pain evaluation questionnaire (JOABPEQ), were evaluated and compared between the domino OVF and non-domino OVF groups. Results: A total of 227 patients were analyzed. The mean age was 80.1 ± 7.3 years and 78% were female. Subsequent domino OVFs were observed in 31 (13.6%) patients within 3 months. An increasing number of prevalent OVFs were significantly associated with domino OVFs (p = 0.01). No significant differences in bone mineral density, type of brace, and anti-osteoporosis medications were found between the two groups. The JOABPEQ (excluding social function), ODI, and VAS were significantly improved after 3 months. Patients with domino OVFs at 3 months had poorer JOABPEQ social life function, ODI, and VAS than those with non-domino OVFs. Conclusions: In this study, the incidence of domino OVFs was 13.6% within 3 months. Domino OVFs had a negative impact on QOL at 3 months and were associated with prevalent OVFs.

Publisher

MDPI AG

Subject

General Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3