HLA-DR and HLA-DQ Polymorphism Correlation with Sexually Transmitted Infection Caused by Chlamydia trachomatis

Author:

Pintea-Trifu Martina-Luciana1ORCID,Vică Mihaela Laura1ORCID,Bâlici Silvia-Ștefana1,Leucuța Daniel-Corneliu2ORCID,Coman Horia George3,Nemeș Bogdan3,Trifu Dragoș-Mihail4,Siserman Costel-Vasile5ORCID,Matei Horea-Vladi1

Affiliation:

1. Department of Cellular and Molecular Biology, Iuliu Hațieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania

2. Department of Medical Informatics and Biostatistics, Iuliu Hațieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania

3. Department of Medical Psychology and Psychiatry, Iuliu Hațieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania

4. Department of Urology, Regina Maria Cluj Hospital, 400696 Cluj-Napoca, Romania

5. Department of Forensic Medicine, Iuliu Hațieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania

Abstract

Background and Objectives: Chlamydia trachomatis (C. trachomatis) represents one of the most prevalent bacterial sexually transmitted diseases. This study aims to explore the relationship between HLA alleles/genotypes/haplotypes and C. trachomatis infection to better understand high-risk individuals and potential complications. Materials and Methods: This prospective study recruited participants from Transylvania, Romania. Patients with positive NAAT tests for C. trachomatis from cervical/urethral secretion or urine were compared with controls regarding HLA-DR and -DQ alleles. DNA extraction for HLA typing was performed using venous blood samples. Results: Our analysis revealed that the presence of the DRB1*13 allele significantly heightened the likelihood of C. trachomatis infection (p = 0.017). Additionally, we observed that individuals carrying the DRB1*01/DRB1*13 and DQB1*03/DQB1*06 genotype had increased odds of C. trachomatis infection. Upon adjustment, the association between the DRB1*01/DRB1*13 genotype and C. trachomatis remained statistically significant. Conclusions: Our findings underscore the importance of specific HLA alleles and genotypes in influencing susceptibility to C. trachomatis infection. These results highlight the intricate relationship between host genetics and disease susceptibility, offering valuable insights for targeted prevention efforts and personalized healthcare strategies.

Funder

IULIU HAȚIEGANU UNIVERSITY OF MEDICINE AND PHARMACY, CLUJ-NAPOCA, ROMANIA

Publisher

MDPI AG

Reference37 articles.

1. World Health Organization (2022). Global Health Sector Strategies on, Respectively, HIV, Viral Hepatitis and Sexually Transmitted Infections for the Period 2022–2030, World Health Organization.

2. Chlamydia, gonorrhoea, trichomoniasis and syphilis: Global prevalence and incidence estimates, 2016;Rowley;Bull World Health Organ.,2019

3. ECDC (2024, March 25). Chlamydia Annual Epidemiological Report 2022. European Centre for Disease Prevention and Control, Available online: https://www.ecdc.europa.eu/sites/default/files/documents/CHLAM_AER_2022_Report.pdf.

4. The nature of selection on the major histocompatibility complex;Apanius;Crit. Rev. Immunol.,1997

5. CCR5 promoter polymorphism and HIV-1 disease progression;McDermott;Lancet,1998

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