Idiopathic Normal Pressure Hydrocephalus and Progressive Supranuclear Palsy: Two Single Entities or Neurodegenerative Overlap Syndrome? A Case Report

Author:

Straka Igor1ORCID,Martinkovicova Alice1,Jezberova Michaela2,Zilka Tomas3,Kosutzka Zuzana1,Saling Marian14,Valkovic Peter14ORCID

Affiliation:

1. 2nd Department of Neurology, Faculty of Medicine, Comenius University in Bratislava, University Hospital Bratislava, 813 72 Bratislava, Slovakia

2. Department of Magnetic Resonance Imaging, Dr. Magnet Ltd., 833 05 Bratislava, Slovakia

3. Department of Neurosurgery, Slovak Medical University, University Hospital–St. Michael’s Hospital, 811 08 Bratislava, Slovakia

4. Institute of Normal and Pathological Physiology, Centre of Experimental Medicine, Slovak Academy of Sciences, 813 71 Bratislava, Slovakia

Abstract

The differential diagnosis of idiopathic normal pressure hydrocephalus (iNPH) and progressive supranuclear palsy (PSP) is difficult. The importance of proper diagnosis is particularly important for iNPH, which can be effectively treated with a ventriculoperitoneal (VP) shunt. In our case report, we present a unique case of a patient with overlapping symptoms and radiological findings of iNPH and PSP. Our patient underwent the VP shunt after a differential diagnostic evaluation which resulted in significant improvement in their clinical condition and quality of life, albeit for a short time.

Funder

Scientific Grant Agency of the Ministry of Education, Science, Research and Sport of the Slovak Republic

European Regional Development Fund

Publisher

MDPI AG

Subject

General Earth and Planetary Sciences,General Environmental Science

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