Update on the Pharmacological Actions of Enoxaparin in Nonsurgical Patients

Author:

Imbalzano Egidio1ORCID,Orlando Luana1,Dattilo Giuseppe1ORCID,Gigliotti De Fazio Marianna1,Camporese Giuseppe2ORCID,Russo Vincenzo3ORCID,Perrella Alessandro4,Bernardi Francesca Futura5,Di Micco Pierpaolo6ORCID

Affiliation:

1. Department of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy

2. General Medicine Department, Thrombotic and Haemorrhagic Disorders Unit, Department of Internal Medicine, University Hospital of Padua, 35131 Padua, Italy

3. Department of Translational Science, University Vanvitelly, 81025 Caserta, Italy

4. Unit Emerging Infectious Disease, Ospedali dei Colli, P.O. D. Cotugno, 80131 Naples, Italy

5. Department of Experimental Medicine, Università degli Studi della Campania Luigi Vanvitelli, 80100 Naples, Italy

6. AFO Medicina, P.O. Santa Maria delle Grazie, ASL Napoli 2 Nord, 80078 Pozzuoli, Italy

Abstract

Low-molecular-weight heparins are a class of drugs derived from the enzymatic depolymerization of unfractionated heparin that includes enoxaparin. Several studies have been performed on enoxaparin in recent years, in particular for the prevention and treatment of venous thromboembolism and for the treatment of acute coronary syndrome. Furthermore, the use of enoxaparin has been extended to other clinical situations that require antithrombotic pharmacological prevention, such as hemodialysis and recurrent abortion. In this review, we report the main clinical experiences of using enoxaparin in the prevention of VTE in nonsurgical patients.

Publisher

MDPI AG

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